Dermal neurofibroma

Keywords— neurofibromin, tumor microenvironment, dermal neurofibroma, NFl, SKPs. 

C. In vivo Ablation of Nfl in the Skin to Induce Dermal Neurofibromas... 

Fig. 2 Topical Apphcation of Tamoxifen to the Skin for In Vivo Deletion of Nfl in SKPs Induced Dermal Neurofibromas...

D. Nfl-Deficient SKPs Give Rise to Classic Dermal Neurofibromas... 

In patients with Neurofibromatosis type I, dermal neurofibromas typically first appear around puberty and, subsequently continue to appear with time. These tumors have also been shown to increase in number and size during... 

Our data reveal a remarkable similarity of SKPs to embryonic neural crest precursors, apparently including the capacity to engender plexiform or dermal neurofibromas. The identity of the tumor cell of origin and the facility for isolation and expansion provides fertile ground for the continued analysis to identify additional factors and signals within the tumor microenvironment that likely play essential roles in neurofibroma genesis. 

Le, L.Q., Shipman, T., Bums, D.K., Parada, L.F. (2009). Cell of origin and microenvironment contribution for NFl-associated dermal neurofibromas. Cell Stem Cell 4 (5) 453-463. 

The development of neurofibromas, the most frequent tumor in NFl, and malignant nerve tumors represent a serious complication of NFl. These are rmiqrre and conqrlex tumors that contain proliferating Schwarm-like cells and other local supporting elements of the nerve fibers, inclrrding perineurial cells, fibroblasts, and blood vessels, as well as infiltration of mast cells. Neurofibromas are classified into three subtypes cutaneous (dermal), srrbcrrtaneorrs and plexiform... 

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