Depsidones natural

In the third paper [53], a new structural class of noncatechol-containing integrase inhibitors, bisaroylhydrazines, was identified by modification of hits obtained in the previously presented studies. These compounds may provide valuable avenues for the development of HIV integrase inhibitors. Finally, also natural products, i.e., lichen acids containing depsides and depsidones, and their synthetic derivatives were identified from 3D database search as novel HIV-1 integrase inhibitors with IC50 values below 50 pM [54],... 

Sargent MV, Stransky PO (1982) Naturally occurring dibenzofurans. Part 2. The synthesis of schizopeltic acid. J Chem Soc Perkin Trans 1 2373-2377 Sargent MV, Vogel P (1976) Depsidone synthesis. IV. 

McEvoy M, Gauslaa Y, Solhaug KA (2007) Changes in pools of depsidones and melanins, and their function, during growth and acclimation under contrasting natural Ught in the lichen Lobaria pulmonaria. New Phytol 175 271-282... 

The more classical chemical procedures of degradation and in particular, total synthesis, have also developed apace with the use of newer reagents and synthetic methods. For instance in 1971 no natural depsidones had been synthesised but in the intervening decade, 15 such compounds have been prepared. Similarly the condensing reagents trifluoroacetic anhydride and dicyclohexylcarbodiimide have made the preparation of lichen depsides a relatively straightforward procedure, so that total synthesis is now a common means of structural confirmation. 

Leuckert C, Ahmadjian V, Culberson CF, Johnson A (1990) Xanthones and Depsidones of the Lichen Lecanora disperia in Nature and of its Mycobiont in Culture. Mycologia 82 370... 

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