Depression glutamate, role

Szerb JC. 1991. Glutamate release and spreading depression in the fascia dentata in response to microdialysis with high K role of glia. Brain Res 542(2) 259-265. 

StrOhle A, Pasini A, Romeo E, Hermann B, Spalletta G, di Michele F, Holsboer F, Rupprecht R (2000) Fluoxetine decreases concentrations of 3a,5a-tetrahydrodeoxycorticosterone (3a,5a-THDOC) in major depression. J Psychiatr Res 34 183-186 StrOhle A, Kellner M, Holsboer F, Wiedemann K (2001) Anxiolytic activity of atrial natriuretic peptide in patients with panic disorder. Am J Psychiatry 158 1514-1516 StrOhle A, Romeo E, di Michele F, Pasini A, Yassouridis A, Holsboer F, Rupprecht R (2002) GABAA receptor modulatory neuroactive steroid composition in panic disorder and during paroxetine treatment. Am J Psychiatry 159 145-147 StrOhle A, Romeo E, di Michele F, Pasini A, Hermann B, Gajewsky G, Holsboer F, Rupprecht F (2003) Induced panic attacks shift GABAA receptor modulatory neuroactive steroid composition. Arch Gen Psychiatry 60 161-168 Szapiro G, Vianna MRM, McGaugh JL, Medina JH, Izquierdo I (2003) The role of NMDA glutamate receptors, PKA, MAPK, and CAMKII in the hippocampus in extinction of conditioned fear. Hippocampus 13 53-58... 

Manahan-Vaughan D (1997) Group 1 and 2 metabotropic glutamate receptors play differential roles in hippocampal long-term depression and long-term potentiation in freely moving rats. J Neurosci 77 3303-3311. 

Robbe, D., Alonso, G., Chaumont, S., Bockaert, J., and Manzoni, O.J. (2002a) Role of p/q-Ca2-i- channels in metabotropic glutamate receptor 2/3-dependent presynaptic long-term depression at nucleus accumbens synapses, J. Neurosci., 22(11), 4346-4356. 

Metabotropic glutamate receptors play an important role in the central nervous system, regulating both neuronal excitability (Colwell and Levine, 1999) and the release of neurotransmitters (Cartmell and Schoepp, 2000). mGluRs may also play an important role in synaptic plasticity (e.g. long term potentiation and long-term depression (Riedel and Reymann, 1996)). Recent studies show that group one... 

In green tissues the enzyme is present in low concentrations compared to the ferredoxin-dependent glutamate synthase (Matoh et al., 1979 Matoh and Ta-kahashi, 1981 Wallsgrove c/a/., 1982 Avillacta/., 1984 Hechter a/., 1988). In mustard cotyledons the enzyme is induced by red light pulses, suggesting a key role for phytochrome. In contrast to the ferredoxin form, the enzyme is induced by nitrate but not depressed by the addition of ammonium ions (Hecht et al., 1988). 

---