Depo-Provera - Medroxyprogesterone acetate

In 1992, the US FDA approved a long-acting contraceptive device containing synthetic progestin medroxyprogesterone acetate (MPA) hormones. Manufactured by Pfizer, Inc., it is sold under the trade name Depo-Provera . It is typically injected into a woman s buttocks or upper arm, and renders her temporarily sterile for up to 3 months. ... 

Medroxyprogesterone acetate and its metabolites are excreted in breast milk, so women who breastfeed should wait until 6 weeks post partum before starting Depo-Provera, when the infant s enzyme system should be more mature. Norethisterone enantate 200 mg (Noristerat) is shorter acting than Depo-Provera, 8 weeks, and is used to provide contraception after administration of the rubella vaccine, and until a partner s vasectomy has taken effect. It can also be used in the longer-term but only on a named patient basis. 

Medroxyprogesterone acetate (medroxyprogesterone-1 7-acetate) Depo-Provera (Pfizer) drug 150 propylene glycol 3350 28.9 polysorbate 80 2.41 sodium chloride 8.68 methylparaben 1.37 propylparaben 0.15 207-209""/ 4.09 intramuscular... 

Long-acting injectable analogues of the sex hormones (16.5) are also used. Depo Provera is injected every 3 months as a microcrystalline aqueous suspension. The active compound, medroxyprogesterone acetate, dissolves slowly as needed. Another compound that is injected once a month is an ester that probably hydrolyzes slowly. 

MEDROXYPROGESTERONE ACETATE (Amen, Curretab, Depo-Provera, Provera)... 

Medroxyprogesterone acetate (Fig. 46.13), administered by injection (Depo-Provera), orally, or delivered via lUD, effectively suppresses the HPO axis, induces anovulation, and reduces serum estrogen levels (83). This prevents menstruation and endometrial implant growth. As a result, endometriosis-related pain is minimized in approximately 90% of the patients. Drug therapy selection should reflect the fact that pharmacological therapy is likely to be required on a chronic basis. The progestins are fairly well tolerated and relatively inexpensive, but they are not without adverse effects. 

The use of an intramuscular progestogen preparation Depo-Provera (150 mg of medroxyprogesterone acetate or 6a-methyl-17a-acetoxyprogesterone) every 3 months does not lead to an increase in the level of plasma vitamin A levels (B14). For example, the plasma... 

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