Deoxyribonucleic acid complex

Churchill ME. Structure of the progesterone receptor-deoxyribonucleic acid complex novel interactions required for binding... 

Mueller, G. C., and K. Kajiwara. 1966. Early-and late-replicating deoxyribonucleic acid complexes inifela nuclei. Biochim. Biophys. Acta, 114 108-115. 

Kievan L, Wang JC (1980) Deoxyribonucleic acid gyrase-deoxyribonucleic acid complex containing 140 base pairs of deoxyribonucleic acid and an a2 32 protein core. Biochemistry 19 5229-5234... 

Chemotherapeutic agents are grouped by cytotoxic mechanism. The alkylating agents, such as cyclophosphamide [50-18-0] and melphalan [148-82-3] interfere with normal cellular activity by alkylation deoxyribonucleic acid (DNA). Antimetabohtes, interfering with complex metaboHc pathways in the cell, include methotrexate [59-05-2] 5-fluorouracil [51-21-8] and cytosine arabinoside hydrochloride [69-74-9]. Antibiotics such as bleomycin [11056-06-7] and doxombicin [23214-92-8] h.a.ve been used, as have the plant alkaloids vincristine [57-22-7] and vinblastine [865-21-4]. 

Deoxy sugars, as we saw in Section 25.7, have an oxygen atom "missing." That is, an —OH group is replaced by an -H. The most common deoxy sugar is 2-deoxyribose, a monosaccharide found in DNA (deoxyribonucleic acid). Note that 2-deoxyribose exists in water solution as a complex equilibrium mixture of both furanose and pyranose forms. 

The nucleic acids, deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), which carry embedded in their complex molecules the genetic information that characterizes every organism, are found in virtually all living cells. Their molecules are very large and complex biopolymers made up basically of monomeric units known as nucleotides. Thus DNA and RNA are said to be polynucleotides. The nucleotides are made up of three bonded (linked) components a sugar, a nitrogenous base, and one or more phosphate groups ... 

The mechanism of action of tin complexes is not known. Deoxyribonucleic acid may not be the target, and involvement in protein synthesis and energy metabolism is possible. 

Only two nucleic acids exist. They are DNA (deoxyribonucleic acid) and RNA (ribonucleic acid). The structural complexity of nucleic acids falls far short of that of proteins. Like proteins, however, nucleic acids are polymers, with nucleotides being the monomer units. 

Yamane T, Davidson N (1962) On the complexing of deoxyribonucleic acid by silver . Biochim Biophys Acta (BBA) 55 609-621, Specialized section on nucleic acids and related subjects... 

Figure 9.12 Deoxy derivatives. These contain one less oxygen atom than the monosaccharide from which they are derived. 2-Deoxyribose is a most important deoxy pentose and is a major constituent of deoxyribonucleic acid (DNA). Deoxy hexoses are widely distributed among plants, animals and microorganisms especially as components of complex polysaccharides. Examples are rhamnose (6-deoxymannose), a component of bacterial cell walls, and fucose (6-deoxygalactose), which is often found in glycoproteins and is an important constituent of human blood group substances.

DNA, short for deoxyribonucleic acid, is the coding machinery of life. The beauty of DNA is in its simplicity that results in the complexity of life. The double helix of DNA is made of the chemicals adenine (A), guanine (G), thymine (T), and cytosine (C). These chemical are bound in long stretches as AT and CG pairs,... 

Nitrenium ions, particularly the arylnitrenium ions, have been proposed as intermediates in deoxyribonucleic acid (DNA) damaging reactions that can ultimately convert a normal cell into a cancer cell. Carcinogenesis is a complex phenomenon. 

Green B. 1967. Effects of silver ions on deoxyribonucleic acid-polycyclic hydrocarbon complexes. Biochem J 104 63-64. 

Moucheron C, Kirsch-De Mesmaeker A, Kelly JM (1997) Photoreactions of ruthenium(ll) and osmium(ll) complexes with deoxyribonucleic acid (DNA). J Photochem Photobiol B Biol 40 91-106... 

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