Deoxyribonucleic acid gyrase

The quinolones and fluoroquinolones are thought to act on the bacterial enzyme deoxyribonucleic acid gyrase (DNA gyrase). This enzyme catalyses the supercoiling of chromosomal DNA into its tertiary structure. A consequence of this is that replication and transcription are inhibited and the bacterial cell s genetic code remains unread. At present, the mechanism by which these agents inhibit DNA gyrase is unclear. 

Kievan L, Wang JC (1980) Deoxyribonucleic acid gyrase-deoxyribonucleic acid complex containing 140 base pairs of deoxyribonucleic acid and an a2 32 protein core. Biochemistry 19 5229-5234... 

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See also in sourсe #XX -- [ ]

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