2 -Deoxycytidine 5 ’ -monophosphate

DBH, dopamine-(3-hydroxylase dCDP, 2 -deoxycytidine 5 -diphosphate dCMP, 2 -deoxycytidine 5 -monophosphate dCTP, 2 -deoxycytidine 5 -triphosphate dCDP, 2 -deoxyguanosine 5 -diphosphate... 

Deoxycytidine 5 -monophosphate 2 -Deoxy-5-fluorouridme 2-Deoxy-P-glucose 2 -Deoxyguanosine 5 -monophosphate 2-Deoxy-P-c/ /ro-mositol... 

For dansyl-2 -deoxyadenosine-5 -monophosphate (dAMP), dansyl-2 - deoxycytidine-5 -monophosphate (dCMP), dansyl-2 -de-xoxyguanine-5 -monophosphate (dGMP), and dansyl-2 -deoxyttiymidine-5 -monophosphate (dTMP). 

Lalitha HN, Ramakumar S, Viswamitra MA (1989) Structure of 5-methyl-2 -deoxycytidine 5 -monophosphate dihydrate. Acta Crystallogr Sect C Cryst Struct Commun 45 1652-1655. doi 10.1107/S0108270189005445... 

Cytosine Deoxycytidine Deoxyeytidyiic acid Deoxycytidine. monophosphate (dCMP) Deoxycytidine diphosphate (dCDP) Deoxycytidine triphosphate (dCTP)... 

An example is given in Fig. 1, where normalized total fluorescence decays are shown for 2 -deoxynucleosides and 2 -deoxynucleotides. In contrast to previous findings our work revealed that the fluorescence decays are complex and cannot be described by single exponentials. They consist of an ultrafast component (< 200 fs) and a slower one (ranging from about 0.4 ps for 2 -deoxyadenosine up to 1.4 ps in the case of 2 -deoxycytidine monophosphate). 

Fig. 21.5 Structure of orthogonal conformers of 2 -deoxyriboadenosine monophosphate (AMP) and 2 -deoxycytidine monophosphate (CMP) with nonplanar pyrimidine ring according to calculations at the B3LYP/aug-cc-pvdz level [4]...

Cytosine (2-oxy-4-aminopyrimidine) Cytidine Deoxycytidine Cytidine monophosphate (CMP) Deoxycytidine monophosphate (dCMP)... 

Zalcitabine enters cells by both carrier-mediated transport and passive diffusion. It is converted to the monophosphate by deoxycytidine kinase and undergoes further phosphorylation by deoxycytidine monophosphate kinase... 

Fig, 2. Nucleotidase isozymes in erythrocytes from the patient with pyrimidine 5 -nucleotidase deficiency ( ) and five healthy controls (1-5) detected using cytidine monophosphate (CMP), thymidine monophosphate (dTMP), deoxycytidine monophosphate (dCMP) as substrates. 

Describe a nucleotide. Draw the structural formula for deoxycytidine monophosphate, analogous to deoxy-adenylic acid, in which cytosine is the organic base. 

Gelbard, A. S., Kim, J. H., and Perez, A. G., 1969, Fluctuations in deoxycytidine monophosphate deaminase activity during the cell cycle in synchronous populations of HeLa cells, Biochim. Biophys. Acta 182 564. 

P-D-Arabinofuranosylcytosine [147-94-4] (ara-C, 16), C H N O, reportedly has had significant therapeutic effects in patients with localized herpes zoster, herpes eye infections, and herpes encephaUtis (33), although several negative results have also been reported (34) (Fig. 2). Ara-C, also known as cytarabine, is quite toxic and is only recommended for very severe viral infections. It is rapidly deaminated in humans to the relatively inactive ara-U Ara-C is converted in the cell to the 5 -monophosphate by deoxycytidine kinase, followed by formation of the corresponding di- and triphosphate. The triphosphate has been shown to inhibit DNA polymerase. 

While mammahan cells reutilize few free pyrimidines, salvage reactions convert the ribonucleosides uridine and cytidine and the deoxyribonucleosides thymidine and deoxycytidine to their respective nucleotides. ATP-dependent phosphoryltransferases (kinases) catalyze the phosphorylation of the nucleoside diphosphates 2 "-de-oxycytidine, 2 -deoxyguanosine, and 2 -deoxyadenosine to their corresponding nucleoside triphosphates. In addition, orotate phosphoribosyltransferase (reaction 5, Figure 34-7), an enzyme of pyrimidine nucleotide synthesis, salvages orotic acid by converting it to orotidine monophosphate (OMP). 

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