Dendritic cell remodeling

Dendritic cells, depending on their degree of maturation, may or may not secrete the contents of the MVE. Rather than being released in the extracellular medium, intralumenal vesicles contained in MIIC compartment can fuse back with the limiting membrane of the multivesicular structure (Kleijmeer et al. 2001). The tetraspanins CD9 and CD81, which have been shown to be involved in cell fusion regulation (Rubinstein etal. 2006), could participate in this cellular event. Moreover, this process of back fusion is related to activation and maturation of dendritic cells. As a consequence, the intracellular exosomal pool of MHC class II molecules (>50% of the total pool in immature DC) rapidly redistributes to the plasma membrane (Kleijmeer et al. 2001). Thus in both cases, dendritic cells and red cells use exosomes to remodel their surface as a function of their differentiation requirements. 

To perform its unique functional role each neuron must regulate a host of intracellular activities, that occur in axons and dendrites distant from the cell nucleus. For example, axonal guidance during development, or remodeling of dendritic spines in response to local input, each involves many different complex control systems that are highly localized and largely autonomous. [ 1 ]. 

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