Demyelination genes involved

In addition to genetic and environmental influences, it is widely accepted that T cell-mediated immune responses are involved in the etiology of MS (reviewed in Frohman et al., 2006a). This is based on the association of MS with genes involved with the immune response, the immunopathology of the disease, the clinical response of MS patients to immunosuppressive and immunomodulatory fieatments, and similarities with experimental immune-mediated demyelinating diseases in animals. 

Multiple sclerosis (MS) is a devastating disease of the CNS that produces demyelination and inflammation. It is believed that its pathogenesis involves an immune reaction against various components of the myelin sheath. In a study by Lock et al. (2002), the gene expression patterns of brain lesions obtained during autopsies of MS patients were examined by microarray cluster analysis. A total of 1080 genes (from 7026 represented... 

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