Demethylation, gene, inhibition

Fig. 7. The model proposed by Szyf to explain the unmethylated status of active genes (for references and further details see Section 5.1). a) Inhibition of acetylation of the tails of core histones prevents active demethyiation. (b) When histone tails are acetylated, as in transcriptionally active chromatin regions, the demethyiase binding to the regions is enhanced, and the DNA is actively demethylated.

Cameron, E.E., Bachman, K.E., Myohanen, S., Herman, J.G. and Baylin, S.B. (1999) Synergy of demethylation and histone deacetylase inhibition in the reexpression of genes silenced in cancer. Nature Genetics, 21, 103-107. 

Suzuki H, Gabrielson E, Chen W et al. A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat Genet 2002 31 141-149. 

Wang LS, Kuo CT, Cho SJ, et al. Black raspberry-derived anthocyanins demethylate tumor suppressor genes through the inhibition of DNMTl and DNMT3B in colon cancer cells. Nutr Cancer. 2013 65(1) 118—125. 

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