Degradation conjugates

What is the effect on toxicity of a compound of larger molecular size Polarity of the molecule Oxidation Reduction Degradation Conjugation ... 

Kislukhin, A. A., Higginson, C. J., Hong, V. R, Finn, M. G. (2012). Degradable Conjugates from Oxanorbomadiene Reagents. Journal of the American Chemical Society, 134, 6491-6497. 

Steroid hormones can be inactivated by conjugation and degradation. Conjugation involves the formation of either glucuronides or aryl sulfates. Steroids are conjugated with glucuronic acid in the presence of a liver microsomal enzyme and UDP-glucuronic acid. 

Detoxification (by degradation, conjugation, etc.) Increase in the concentration of the metabolite which competes with the inhibitor for a binding site... 

Because of the multiple conjugated olefinic stmcture in the molecule, pure crystalline carotenoids are very sensitive to light and air and must be stored in sealed containers under vacuum or inert gas to prevent degradation. Thus, commercial utilization as food colorings was initially limited however, stable forms were developed and marketed as emulsions, oil solutions and suspensions, and spray-dried forms. 

One limitation of enzyme replacement therapy is the targeting of enzyme proteins to appropriate sites of substrate accumulation. Administration of a cholesterol esterase conjugated to albumin results in the degradation of pathologic cholesterol ester accumulations within the lysosomes of fibroblasts from a patient with cholesterol ester storage disease (246). 

Thermal stability of polyazines of the third group, i.e., polymers with conjugated sections separated by aliphatic blocks, is determined by the thermal stability of the latter. The degradation process takes place gradually, and it is not accompanied by any considerable heat effects41,117-. ... 

The effect of local activation accounts for such features of PCSs as catalytic and stabilizing properties, autocatalysis, specific properties of thermal degradation, structural modification, and a number of other phenomena typical of polymers with a system of conjugated bonds. 

---