Glutathione conjugates degradation

Figure 7.29 The metabolic activation of hexachlorobutadiene. The glutathione conjugate is degraded to a cysteine conjugate in two stages involving the action of (1) y-glutamyltransferase and (2) cysteinyl glycinase.

Figure 12. Degradation of glutathione conjugates of 2,2, 5,5 -tetrachloroblphenyl In water and methanol as suggested by Preston et al. (180).

Jin, L. Davis, M.R. Kharasch, E.D. Doss, G.A. Baillie, T.A. Identification in Rat Bile of Glutathione Conjugates of Eluoromethyl 2,2-difiuro-l-(trifluromethyl)vinyl Ether, a Nephrotoxic Degradate of the Anesthetic Agent Sevoflurane, Chem. Res. Toxicol. 9, 555-561 (1996). 

L Jin, MR Davis, ED Kharasch, GA Doss, TA Baillie. Identification in rat bile of glutathione conjugates of fluoromethyl 2,2-difluoro-l-(trifluoromethyl)vinyl ether, a nephrotoxic degradate of the anesthetic agent sevoflurane. Chem Res Toxicol 9 555, 1996. 

Ester hydrolysis is the most important microbial degradation of diazinon, whereas mammals produce glutathione conjugates and oxidation products. 

Many of the metabolic transformations for pesticide detoxification that occur in plants are also found in prokaryotes, especially co-metabolic transformations. Glutathione conjugation of the chloroacteamide herbicides is observed in many species of gram negative bacteria including Pseudomonas sp and various members of the Enterobacteriaceae (57). Most of the degradative steps for FE metabolism in plants (de-esterification to F, and subsequent... 

---