Defensins, functions

Describe briefly the functions of each of the folowing antibodies, defensins, cytokines, complement, MHC proteins, B cells, T cells, dendritic cells, monocytes, macrophages, and neutrophils. 

VSL 3 probiotic mixture Improves epithelial barrier function Induces human p-defensin, hBD-2 gene expression Schlee et al. (2008)... 

Fellermann et al., 2003). The deficient induction of (i-defensins may be due to mutations of the intracellular peptidoglycan receptor NOD2 and to changes in the intracellular transcription by NFkB. The resulting deficient mucosal barrier function may lead to a permanent but slow bacterial invasion, triggering the inflammatory process and probably autoimmunity. 

In addition to their direct antimicrobial activity [15] defensins, whose functional overlap with chemokines has recently been confirmed, enhance phagocytosis, promote neutrophil recruitment, boost the production of proinflammatory cytokines and regulate complement activation, thus upregulating innate host inflammatory defenses [15]. They also contribute to adaptive immune responses by selectively attracting immature DCs, CD8+ T cells,... 

Clarke DJ, Campopiano DJ (2006) Structural and functional studies of defensin-inspired peptides. Biochem Soc Trans 34 251-256... 

In mammalians, mono-ADP-ribosylation appears to take place primarily on the surface of immune cells. The corresponding transferases are either anchored in the plasma membrane via glycosylphosphatidylinositol (GPI) or secreted. For example, in the lung, the antimicrobial function of a-defensin-1, which is secreted by immune cells, is diminished by mono-ADP-ribosylation. ... 

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