Defensins antiviral activity

Cooper EL. (2004) Commentary on Traditional and modem biomedical prospecting Part 11 — the benefits by Muller WEG Schroder HC, Wiens M, Perovic-Ottstadt S, Batel R, Muller IM. Anti-protozoa and antiviral activities of non-cytotoxic truncated and variant analogues of mussel defensin by Roch P, Beschin A, Bernard E. Evid Based Complement Alternat Med 1 207-209. 

FALCO A, CHICO V, MARROQuf L, PEREZ L, COLL JM, ESTEPA A (2008), Expression and antiviral activity of a beta-defensin-like peptide identified in the rainbow trout Oncorhynchus mykiss) EST sequences . Mol Immunol, 45,757-65. 

FALCO A, MAS V, TAFALLA c, PEREZ L, COLL JM, ESTEPA A. Dual antiviral activity of human alpha-defensin-1 against viral haemorrhagic septicaemia rhabdo-viras (VHSV) inactivation of vims particles and induction of a type I interferon-related response. Awftviro/ Res 2007 Nov 76(2) lll-23. 

Proteomics have been used to develop biomarkers. This is achieved by comparative analysis of protein expression in healthy and diseased tissues to identify expressed proteins to be used as new markers, by analysis of secreted proteins in cell lines and primary cultures, and by direct serum protein profiling. MALDI seems to be a good technique for direct protein analysis in biological fluids (e.g., the identification of the small proteins-defensin 1, 2 and 3 as related to the anti-HIV-1 activity of CD8 antiviral factor). 

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