Dedrick

Zaharko DS, Dedrick RL, Bischoff KB, Longstreth JA, Oliverio VT. Methotrexate tissue distribution prediction by a mathematical model. / Natl Cancer Inst 1971 Apr 46(4) 775-84. 

Dedrick R, Bischoff KB, Zaharko DS. Interspecies correlation of plasma concentration history of methotrexate (NSC-740). Cancer Chemother Rep 1970 Apr 54(2) 95-101. 

Atkinson AJ, Daniels CE, Dedrick RL, Grudzinskas CV, Markey SP. Principles of clinical pharmacology. San Diego Academic Press, 2001... 

Lntz RJ, Dedrick RL, Matthews FEB, Fling TE, Anderson MW. A preliminary pharmacokinetic model for several chlorinated biphenyls in the rat. Drug Metab Dispos 1977 5 386-396... 

Farris FF, Dedrick RL. 1993. Absorption of methylmercury from hair ingested by rats. Life Sci 53 1023-1029. 

Farris FF, Dedrick RL, Allen PV, Smith JC. 1993. Physiological model for the pharmacokinetics of methyl mercury in the growing rat. Toxicol Appl Pharmacol 119 74-90. 

F. F. Farris, R.L. Dedrick, P.V. Allen and J.C. Smith, Physiological model for the pharmacokinetics of methyl mercury in the growing rat. Toxicol. Appl. Pharmacol., 119 (1993) 74—90. P. Franklin, An Introduction to Fourier Methods and the Laplace Transformation. Dover, New York, 1958. 

The use of a membrane-limited two- or three-subcompartment organ model is indicated if tissue drug concentrations do not decline in parallel with drug concentrations in plasma or blood. A formal criterion has been given by Dedrick and Bischoff [10] such that if... 

RL Dedrick, KB Bischoff. Pharmacokinetics in applications of the artificial kidney. Chem Eng Prog Symp Ser 64 32-44, 1968. 

H Boxenbaum, R Ronfeld. Interspecies pharmacokinetic scaling and the Dedrick plots. Am J Physiol 245 R768-R774, 1983. 

FG King, RL Dedrick. Physiological model for the pharmacokinetics of 2 -deoxyco-formycin in normal and leukemic mice. J Pharmacokin Biopharm 9 519-534, 1981. 

Joshi, A., Bauer, R., Kuebler, P, White, M., Leddy, C., Compton, P., Garovoy, M., Kwon, P., Walicke, P., and Dedrick, R. 2006. An overview of the pharmacokinetics and pharmacodynamics of efalizumab a monoclonal antibody approved for use in psoriasis. Journal of Clinical Pharmacology 46(1), 10-20. 

Bungay PM, Dedrick RL, Matthews HB. 1979. Pharmacokinetics of halogenated hydrocarbons. Ann N Y Acad Sci 320 257-270. 

The authors gratefully acknowledge the enthusiastic technical assistance of J. B. Anderson, P. Fenstermacher, E. A. Guarino, M. A. Kinter, A. S. Owens, G. Reich and K. Sutermeister. Discussions with our colleagues J. M. Collins, R. L. Dedrick, J. D. Fenstermacher, J. B. Pritchard and D. P. Rail, were extremely helpful in shaping these studies. The secretarial assistance of C. A. 

Atkinson AJ Jr, Daniels CE, Dedrick RL, et al. Principles of Clinical Pharmacology, Academic Press, San Diego, CA, 2001. 

Bungay PM, Morrison PF, Dedrick RL. 1990. Steady-state theory for quantitative microdialysis of solutes and water in vivo and in vitro. Life Sci 46(2) 105-119. 

Bobo RH, Laske DW, Akbasak A, Morrison PF, Dedrick RL, Oldfield EH, Proc. Natl Acad. Sci. 7/541994,97,2076-2080. 

Zunkeler B, Carson RE, Olson J, Blasberg RG, DeVroom H, Lutz RJ, Saris SC, Wright DC, Kammerer W, Patronas NJ, Dedrick RL, Herscovitch P, Oldfield EH, J. Neurosurg. 1996, 85, 1056-1065. 

In chemical toxicology, since it has been long known that the acute toxic threshold (LDjo) of a chemical is approximately the same in different species if the dose is expressed as a finction of body weight, this fraction has become the conventional unit in which to express the doses of different chemicals (Dedrick, 1973). The relationship is not precise, however for some chemicals, the LD50 values, even when expressed in these units, can differ by orders of magnitude. 

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