De Mello

Poly(acrylic acid) and its salts have been known to have useful binding properties for some thirty years they have been used for soil consolidation (Lambe Michaels, 1954 Hopkins, 1955 Wilson Crisp, 1977) and as a flocculant (Woodberry, 1961). The most interesting of these applications is the in situ polymerization of calcium acrylate added to soil (de Mello, Hauser Lambe, 1953). But here we are concerned with cements formed from these polyacids. 

WooTTON, R. C. R., Foett, R., de Mello, a. j.. On-chip generation and reaction of unstable intermediates -mondithic nanoreactors for diazonium chemistry azo dyes. Lab. Chip 2 (2002) 14N-21N. 

Mitchell, M. C., Spikmans, V., Bessoth, F., Manz, a., de Mello, A., Towards organic synthesis in microfluidic devices multicomponent reactions for the construction of compound libraries, in van den Berg, A., Olthuis, W., Bergveld,... 

Conegero-Sanches AC, Lopes GC, Nakamura CV, Dias Filho BP, Palazzo de Mello JC (2005) Braz J Pharm Sci 41 101... 

Del Castillo, J., De Mello, W.C. and Morales, T. (1963) The physiological role of acetylcholine in the neuromuscular system of Ascaris lumbricoides. Archives Internationale Physiologie Biochimie 71, 741-757. 

Benninger, R. K. P., Koc, Y., Hofmann, O., Requejo-Isidro, J., Neil, M. A. A., French, P. M. W. and de Mello, A. J. (2006). Quantitative 3D mapping of fluidic temperatures within microchannel networks using fluorescence lifetime imaging. Anal. Chem. 78, 2272-8. 

Koole R, van Schooneveld MM, Hilhorst J, Castermans K, Cormode DP, Strijkers GJ, De Mello Doneg C, Vanmaekelbergh D, Griffioen AW, Nicolay K, Fayad ZA, Meijerink A, Mulder WJ (2008) Bioconjug Chem 19(12) 2471... 

Baranov PG, Orlinskii SB, de Mello Donega C, Meijerink A, Blok H, Schmidt J (2009) Phys B Condensed Matter 404 4779... 

Jakeway, S. C. de Mello, A. J., Chip based refractive index detection using a single point evanescent wave probe, Analyst 2001, 9, 1505 1510... 

De Mello et al. have constructed a so-called pSYNTAS (miniaturized synthesis and total analysis system). The system was used to perform an Ugi-type reaction to form several a-aminoacetamides from amines, isocyanates and formaldehyde in the presence of water (Scheme 25) [56-58]. The reported system consists of a glass/silicon nanoreactor [59] in connection to a TOF-MS for the real-time online analysis of the reaction stream. Reactions were conducted in the 600 nl volume chip under continuous flow of 20-2 pl/min flow rate. Reduced flow rates resulted in increased outputs. The analyzed outlet flow showed high yields of the desired products with small quantities of starting materials and intermediates (no exact yields were reported). 

De Mello et al. [68] have produced several azo-dyes by the conversion of an aromatic amine to a diazonium salt and its reaction with (3-naphtol in a monolithic nanoreactor (Fig. 5). 

Miller PW, Long NJ, de Mello AJ et al (2006) Rapid formation of amides via carbonylative coupling reactions using a microfluidic device. Chem Commun 5 546-548... 

Mitchell MC, Spikmans V, de Mello AJ (2001) Microchip-based synthesis and analysis control of multicomponent reaction products and intermediates. Analyst 126(1 ) 24—27... 

It approximates the expectation of the stochastic formulation (usually called the true problem) and can be solved using deterministic algorithms. The SAA method was used among others by Shapiro and Homem-de-Mello (1998), Mark, Morton and... 

Wood (1999), Linderoth, Shapiro and Wright (2002) for stochastic linear problems, Kleywegt, Shapiro and Homem-De-Mello (2001), Verweij et al. (2003) for stochastic integer problems, and Wei and Realff (2004), Goyal and Ierapetritou (2007) for MINLP problems. Problem (7.15) can be solved iteratively in order to provide statistical bounds on the optimality gap of the obj ective function value. For details and proofs see N orkin, Pflug and Ruszczysk (1998) and Mark, Morton and Wood (1999). The procedure consists of a number of steps as described in the following section. 

Kleywegt, A.J., Shapiro, A., and Homem-De-Mello, T. (2001) The sample average approximation method for stochastic discrete optimization. SIAM Journal on Optimization, 12, 479. 

Shapiro, A. and Homem-de-Mello, T. (1998) A simulation-based approach to two stage stochastic programming with recourse. Mathematical Programming, 81, 301. 

De Mello, J.P., Petereit, F., and Nahrstedt, A., Prorobinetinidins from Stryphnodendron adstrin-gens. Phytochemistry, 42, 857, 1996. 

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