Daunorubicin dosage

Daunorubicin (daunomycin, rubidomycin Cerubidine, others) is available for intravenous use. The recommended dosage is 30 to 60 mg/m daily for 3 days. The agent is administered with appropriate care to prevent extravasation, as severe local vesicant action may result. Total doses greater than 1000 mg/m are associated with a high risk of cardiotoxicity. A daunorubicin citrate liposomal product (Daunoxome) is indicated in the treatment of AIDS-related Kaposi s sarcoma. It is given in a dose of 40 mg/m infused over 60 minutes and repeated every 2 weeks. Patients should be advised that the drug may impart a red color to the urine. 

Despite their usefulness, both daunorubicin and doxorubicin have several acute and long-term side effects. The most severe of these is cumulative cardiotoxicity [14], since it limits the dosage that can be prescribed. In addition, the emergence of multi-drug resistance in cancer cells upon long-term treatment poses serious problems in the clinic. Therefore it is not surpris-... 

Anthracyclines in general cause a wide range of side effects, including nausea and vomiting, gastrointestinal disturbances, myelosuppression, hepatotoxicity, and cumulative car-diotoxicity (4) The most destructive side effect of anthracyclines is cumulative car-diotoxicity, which limits lifetime dosages of daunorubicin to 500-600 mg/m and... 

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