Danocrine - Danazol

Endometriosis is abnormal growth of endometrial tissue in the peritoneal cavity. Women with this disorder have dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Danazol (Danocrine) is a 2,3-isoxazol derivative of 17a-ethynyl testosterone (ethisterone) that has weak virilizing and protein anabolic properties. It is effective in endometriosis through its negative feedback... 

The anabolic steroids include danazol, mcthyltestosteronc, ethylestrenol, methandrostenolone, nandrolonc, oxandrolone, oxymetholone, stanozolol, and tetraliy-drogestrinone (brand names include Anadrol, Anavar, Danocrine, Dianabol, Metan-dren, and Winstrol). Although some may be taken orally or topically, others must be injected to be effective (see Table 14.2). The metabolism and elimination of steroids arc variable. Steroids can be detected reliably in urine for 4 to 14 days after use, but there are reports of positive urine tests as long as 13 months after the use of nan-drolone (Marshall, 1988). 

Liversidge and Cundy reported a dramatic increase in the oral bioavailabiUty of a nanoparticulate danazol composition relative to a micronized composition when administered to fasted beagle dogs. Danazol, sold under the ttadename Danocrine , is a synthetic steroid used to tfeat endometriosis. It has an aqueous solubility of approximately lOpg/mL and has the chemical sttucture shown in Fig. 3. 

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