Danishefskys Total Synthesis of the CP-Molecules

For an example, see J.E. Baldwin, R.M. Adlington, F. Roussi, P. G. Bulger, R. Marquez, A. V.W. Mayweg, Tetrahedron 2001, 57, 7409. Many of these biogenetic proposals are related to ideas advanced far earlier for similar natural products, as can be gleaned from D, H. R. Barton, J. K. Sutherland, J. Chem. Soc. 1965, 1769, and other papers in this series. 

For example using this reagent to create W-based heterocycles, see a) L. Vo-Quang, Y. Vo-Quang, J. HeterocycL Chem. 1982, 79, 145 b) B. E. Landbeig, J.W. Lown, J. Chem. Soc., Perkin Trans. 1 1975, 1326 c) R. Huisgen, M. Seidel, G. Wallbillich, H. Knupfer, Tetrahedron 1962, 77, 3. 

For an elegant example of this concept, see P. Linnane, N. Magnus, P. Magnus, Nature 1997, 385, 799. 

An equally enticing interpretation for the formation of colombiasin A (1), first advanced by the Nicolaou group in 2001, relies instead upon dehydration of the hydroxy group at C-9 in 2 with concurrent isomerization leading to the diene system 5. Due to the proximal nature of the putative diene and dienophile units in 5, a productive Diels—Alder cycloaddition would then lead directly to 1 with concomitant formation of the adjacent and daunting quaternary centers. In this chapter, we shall focus our attention 

Having reduced the synthetic problem to the creation of quinone 

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