Danger Man

Its success in America and the popularity of British shows like I, Claudius and Upstairs, Downstairs suggested that the time was right for a first-rate thriller series. In the past, there had been several solid British spy shows, like Danger Man and its curious spin-off The Prisoner, as well as less serious programs like The Avengers, which had proved very popular in the United States. 

Chemicals are ubiquitous as air, carbohydrates, enzymes, lipids, minerals, proteins, vitamins, water, and wood. Naturally occurring chemicals are supplemented by man-made substances. There are about 70000 chemicals in use with another 500-1000 added each year. Their properties have been harnessed to enhance the quality of life, e.g. cosmetics, detergents, energy fuels, explosives, fertilizers, foods and drinks, glass, metals, paints, paper, pesticides, pharmaceuticals, plastics, rubber, solvents, textiles thus chemicals are found in virtually all workplaces. Besides the benefits, chemicals also pose dangers to man and the environment. For example ... 

We are just beginning to understand the effects that trace elements and compounds may have on man and his environment. For most of these we do not know what the toxic levels in man and animals are. Not only are some very dangerous in very small amounts, like cadmium and mercury, but others are necessary. 

The most dangerous in their long-term effects are the tailing dumps containing radio-active waste, which are also located in the vicinity of the Dnepr bed or near smaller rivers in the Dnepr catchment basin. Many tailing dump levees and toxic radio-active waste hoarder dams are in extremely poor condition. They can be easily destroyed by natural factors (minor earthquakes, floods, rise of subterranean waters) or by man-made acts (like a terrorist act with the use of explosives), with all ensuing consequences. 

V I see by your eagerness, and the wonder and hope which your eyes express, my friend, that you expect to be informed of the secret with which I am acquainted that cannot be listen patiendy until the end of my story, and you will easily perceive why I am reserved upon that T subject. I will not lead you on, unguarded and ardent as I then was, to your destruction and infallible misery. Learn from me, if not by my precepts, at least by my example, how dangerous is the acquirement of knowledge, and how much happier that man is who believes his native town to be the world, than he who aspires to become greater than his (10) nature will allow. 

The NIOSH immediately dangerous to life and health (IDLH) value (NIOSH 1994) is greater than the 30-min AEGL-3. NIOSH based their recommended exposure limit (REL) on the statement by Flury and Zernik (1931) that 45-54 ppm could be tolerated by man for 0.5 to 1 h without immediate or late effects. Although the Flury and Zernik (1931) data are based on animal studies, NIOSH did not apply a UF. 

The dangerous properties of acute toxicity, irritation, corrosivity, sensitisation, repeated-dose toxicity and CMR are evaluated in terms of their potential toxic effects to workers, consumers and man exposed indirectly via the environment, based on the use for each stage in the lifecycle of the substance from which exposure can occur. Risk assessment is also required if there are reasonable grounds for concern for potential hazardous properties, e.g., from positive in vitro mutagenicity tests or structural alerts. The risk assessment involves comparing the estimated occupational or consumer exposure levels with the exposure levels at which no adverse effects are anticipated. This may be a quantitative risk assessment, based on the ratio between the two values, or a qualitative evaluation. The principles of human health risk assessment are covered in detail by Illing (a.30) and more briefly in Chapter 7 of (73). 

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