Danaparoid sodium

Danaparoid sodium Prepared from animal gut mucosa contains heparin sulfate (84%), dermatan sulfate (12%), and chondroitin sulfate (4%)... 

Common Name Danaparoid sodium Dermatan sulfate... 

In patients with HIT and evidence of thrombosis, danaparoid sodium, hirudin or argatroban (see p. 577) should be substituted. Warfarin should not be started until adequate anticoagulation has been achieved with one of these agents and the platelet count has returned to normal as skin necrosis or worsening thromboembolism may result. LMW heparins are unsuitable as the antibody may be cross-reactive. 

Tardy B, Tardy-Poncet B, Viallon A, Piot M, Mazet E. Fatal danaparoid-sodium induced thrombocytopenia and arterial thromboses. Thromb Haemost 1998 80(3) 530. 

Magnani HN. Orgaran (danaparoid sodium) use in the syndrome of heparin-induced thrombocytopenia. Platelets 1997 8 74. 

Orgaran (Danaparoid sodium). Organon Canada Ltd. Canadian product monograph, June 2001. 

Danaparoid sodium, 32.631 Daptomycin, muscle damage, 30.309 Deferiprone, cardiac siderosis, 29.235 Deferoxamine, 16.247 bone dysplasia, 23.241 cardiac siderosis, 29.235 bone dysplasia, 23.241 cardiac siderosis, 29.235 yersiniosis, 11.215... 

In patients who are intolerant to heparin, a mixture of heparin, dermatant sulphate and chondroitin sulphate (Danaparoid sodium) may be used as an anticoagulant. The antithrombotic activity of other sulphated polysaccharides is well known. Recently (2008) there was some concern about contamination of heparin with over-sulphated chrondroitin sulphate, which is believed to have led to a number of deaths in the USA. Simple analytical methods are not adequate for the quality control of... 

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