DADMe

Copolymers of diallyl dimethyl ammonium chloride [7398-69-8] with acrylamide have been used in electroconductive coatings (155). Copolymers with acrylamide made in activated aqueous persulfate solution have flocculating activity increasing with molecular weight (156). DADM ammonium chloride can be grafted with cellulose from concentrated aqueous solution catalysis is by ammonium persulfate (157). Diallyl didodecylammonium bromide [96499-24-0] has been used for preparation of polymerized vesicles (158). 

Furthermore, D- and L-prolyl-(l,l-dimefhyl)-l,2-diaminoethyl (Pro-DADME) segments have been used successfully to connect two y9-peptide strands via their C-termini and to promote the formation of a parallel hairpin (e.g. 123) in both solution (CD3OH) and solid state (Fig. 2.32) [196]. 

Fig. 2. 32 Parallel hairpin formation in a j3-peptide by incorporation of a D-Pro-DADME turn segment [195]. Summary of the long-range NOE observed by NMR in CD3OH which is consistent with a hairpin conformation together with the structure of 123 in the...

Examples of fluorine-containing imino sugars as partial structures of PNPs have been reported. The S -deoxy-S -fluoro compound 116 ( S -F-Imucillin H, Scheme 29) was found to be a nanomolar inhibitor of human PNP (1 nM) as well as that of Plasmodium falciparum (A) 60 nM).237 2,-Deoxy-2,2 -difluoro derivative 117 ( -diF-immucillin-H ) exhibited slightly more inhibitory power against the microbial enzyme and an enhanced selectivity of more than three orders of magnitude (ATj 1.4 nM vs. 15 pM).238 Another type of inhibitor, the 3-fluoro compound 118 ( F-DADMe-immucillin-H ) was shown a potent picomolar inhibitor of the human enzyme (Kf 32 pM), with some selectivity over the Plasmodium phos-phorylase (2.6 nM), whereas the enantiomer 119 was 50- to 100-fold less active 239,240... 

Figure 7-9. Oxacarbenium ion transition state, Immucillin-H and DADMe-Immucillin-H are shown. The nomenclature - DADMe is (4 -Deaza-l -Aza-2/-Deoxy-l/,N-9-Methylene)-Immucillin-H. On die right, the molecular electrostatic potential surfaces (MEP) for the oxacarbenium/hypoxanthine pair at die transition state, Immucillin-H and DADMe-Immucillin-H are shown. MEP were calculated at HF/STO-3G theory level for optimized geometry at BlLYP/6-31G(d) theory level and visualized by Molekel 4.0 at electron density of 0.008 electron/bohr...

Figure 7-10. Immucillin transition state analogues and their corresponding DADMe-modifications. Initial (Kj) or slow-onset equilibrium dissociation constants (Kj ), are shown for human (bold) and P. falciparum PNP (italic)...

DADMe - simple but logic modification leading to great improvement... 

A. The DADMe modification also provides a favorable charge localization to place the cation at the l -position. The pKa of l -pyrrolidine nitrogen in DADMe system is 8.575 and provides the cationic nitrogen to ion pair with phosphate in the active site of phosphorylases. The N4 nitrogen of Immucillin-H has a pKa of 6.972 and is cationic in the active site, however the Cl -C9 distance is only... 

Figure 7-11. 5 -p-Cl-phenylthio-DADMe-Immucillin-A is a femtomolar transition state analogue for E.coli 5 -methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN). Initial (Kj) and equilibrium (Kf) dissociation constant are shown... 

Figure 7.2 Mycophenolic acid (an uncompetitive inhibitor), nevirapine (a non-competitive inhibitor), DADMe-Immh (a slow off-rale reversible inhibitor), busulfan (a non-specific affinity label), omeprazole (prodrug of an irreversible inhibitor), sulbactam, finasteride (both mechanism-based inactivators), and cinacalcel (an allosteric activator).

BTDE/NE/3,3 -DADM Composites and solution BTDE/NE/Jeffamine AP-22... 

Two other important aromatic amine curing agents are 4,4 -diaminodiphenylmethane (DADM) and 4,4 -diaminodiphenyl sul-phone (DADS)... 

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