Cytidylic acid, 2-deoxy-5 -

Kakiuchi, N., Marck, C., Rousseau, N., Leng, M., De Clerq, E. and Guschlbauer, W. (1982) Polynucleotide helix geometry and stability. Spectroscopic, antigenic and interferon-inducing properties of deoxyribose-, ribose-, or 2 -deoxy-2 -fluororibose-containing duplexes of poly(inosinic acid), poly(cytidylic acid). J. Biol. Chem., 257, 1924-1928. 

It was concluded39 from these studies that the two nucleotides obtained by enzymic hydrolysis of the deoxyribonucleic acid of T2 bacteriophage are 2-deoxy-5 -(hydroxymethyl)cytidylic acid and a glucose derivative thereof. It was also concluded that the glucose residue is affixed to the pyrimidine portion of the nucleotide and nucleoside of 5-(hydroxymethyl)-cytosine and, on the basis of the near identity of the spectra of the two nucleotides of 5-(hydroxymethyl)cytosine, it was suggested that the hexose is attached to the hydroxymethyl group of the pyrimidine. 

Deoxycytidirre 6 -morrophosphate 2 -Deoxy-6 -cytidylic acid CgHyNgOgP 1032-66-1 307.197 pow 183 dec ... 

Cytidine phosphates cytidine S -monophosphate (CMP, cytidylic acid, M, 323.2), cytidine 5 -diphos-phate (CDP, M, 403.19) and cytidine 5 -triphosphate (CTP, M, 483.16). For structure, see e. g. Pyrimidine biosynthesis. CTP is a precursor of RNA synthesis, while deoxy-CTP is a precursor of DNA synthesis. CDP may be regarded as the coenzyme of phospholipid biosynthesis (see Membrane lipids) (activated choline is CDP-choline). Glycerol and the sugar alcohol, ribitol, are also activated by bonding to CDP (see Nucleoside diphosphate sugars). Reduction of ribose... 

Cytosine arabinoside p-D-Furanose-/orw 5 -Phosphate, C-221 Cytosine arabinoside p-D-Furanose-/orw 5 -TViphosphate, C-221 2 -Deoxy-5 -adenylic acid, D-28 2 -Deoxyadenosine 5 -Diphosphate, D-28 2 -Deoxyadenosine 5 -TViphosphate, D-28 2 -Deoxy-3 -adenylic acid, D-28 2 -Deoxyadenylyl-(3 ->50-2 -deoxyguanosine, D-31 2 -Deoxycytidine -D-form 5 -Diphosphate, D-43 2 -Deoxycytidine -D-form 5 -Phosphate, D-43 2 -Deoxycytidine -D-form 5 -Triphosphate, D-43 2 -Deoxy-3 -cytidylic acid, D-43 2 -Deoxycytidylyl-(3 50-2 -deoxyadenosine, D-45 2 -Deoxycytidylyl-(3 50-2 -deoxyadenylyl-(3 50-2 -deoxyguanosine, D-46... 

Crotonic acid anhydride 1454 Cyclopentanoic acid 2663 2 -Deoxy-5 -cytidylic acid 2801... 

Since the pyrimidines of RNA as well as those of DNA were labeled after administration of isotopic cytidine, it was suggested that there had lieen a conversion of a pyrimidine ribonucleoside to a pyrimidine deoxy-ribonucleoside (317). It was reasoned that cytidine could not have lieen split to cytosine and then reincorporated into deoxycytidine, because cytosine was not utilized for the synthesis of nucleic acid p3uimidines (303). The suggested conversion may possibly have occurred at the nu cleotide level, thus, cytidylic acid may have been the intermediate in the transformation of RNA to DNA pyrimidines. 

Acetamido-2-deoxy-p-D-glucose l-(dihydrogen phosphate). A-271 V-Acetylgalactosamine 1-phosphate, A-211 V-Acetyl-p-neuraminic acid 2-(hydrogen 5 -cytidylate), A-21... 

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