Cystic fibrosis water absorption

Q10 Pancreatic insufficiency occurs in approximately 80% of cystic fibrosis patients. There is a marked reduction in the water, electrolyte and enzyme content of pancreatic secretion. Because of deficient digestive enzymes, there is inadequate digestion and absorption of nutrients and some nutritional deficiency occurs. 

D. Because cystic fibrosis leads to pancreatic damage and diminution of the abihty to secrete HCO3 and pancreatic digestive enzymes with the result that fat and protein are absorbed poorly. Retinol is a fat-soluble vitamin that must be absorbed along with lipid micelles other fat-soluble vitamins are E, D, and K. The other vitamins hsted are water-soluble and their absorption is not significantly affected. 

So far, Pulmozyme is the first pulmonary drug based on a protein. It contains rhDNase, an enzyme active in the treatment of cystic fibrosis. This, however, is a locally active drug, which does not require absorption but only sufficient deep lung deposition. The water-based solution is aerosolized by a large nebulizer with application phases of 15 to 30 min, which strongly restricts the use of the drug. In general, development of handy carry-on nebulizers is of utmost importance for... 

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