Cystic Fibrosis bile acid

Excessive secretion of gastric acid, associated with Helicobacter pylori infection, can result in the development of gastric and duodenal ulcers small changes in the composition of bile can result in crystallization of cholesterol as gallstones failure of exocrine pancreatic secretion (as in cystic fibrosis) leads to undernutrition... 

The ABC1 protein is a member of a large family of multidrug transporters, sometimes called ABC transporters because they all have ATP-binding cassettes they also have two transmembrane domains with six transmembrane helices (Chapter 11). These proteins actively transport a variety of ions, amino acids, vitamins, steroid hormones, and bile salts across plasma membranes. The CFTR protein that is defective in cystic fibrosis (see Box 11-3) is another member of this ABC family of multidrug transporters. 

C. Colombo. S. Ariati, L. Curcio, R. Maiavacca, M. Garatti, M, Ronchi, C. Corbetta, and A. Quinta. Effect at taurine supplementation on fat and bile acid absorption in friwita with cystic fibrosis. Scand, J, Gastroenterol. 23(suppl 143) 125 (1988). 

Vitamin K absorption depends on both bile acids and pancreatic enzymes to create micelles. Malabsorption resulting from diseases of the small intestine or pancreas—such as cystic fibrosis, Crohn s... 

ABNORMAL FECAL BILE ACID EXCRETION IN CYSTIC FIBROSIS PHYSIOPATHOLOGICAL MECHANISM AND CLINICAL IMPLICATIONS... 

L. Morin, and R. Lasalle, Relationship between bile acid malabsorption and pancreatic insufficiency in cystic fibrosis. Gut, 17 295 (1976). 

C. M. Anderson, Aspects of bile acid metabolism in cystic fibrosis, Archs.Pis.Childh., 50 769 (1975). 

Evaluation of an oral ursodeoxycholic acid load in the assessment of bile acid malabsorption in cystic fibrosis, Dig.Dis.Sci., 28 306 (1983). 

Huang, Effect of cimetidine and pancreatic enzymes on serum and fecal bile acids and fat absorption in cystic fibrosis. Gastroenterology, 78 950 (1980). 

A. Weber, and C. Morin, The fecal microflora and bile acids in children with cystic fibrosis. Am.J.Clin.Nutr., 32 2404 (1979). 

Fugazza, and A. Giunta, Bile acid malabsorption in cystic fibrosis with and without pancreatic insufficiency,... 

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