Cystic fibrosis, amiloride

Nebulizer Solutions The potential interactions that can occur in nebulizer solutions are subject to simple solution chemistry. A few excipients are employed in nebulizer products, notably sodium chloride to achieve isotonicity with body fluids. There are some rare examples in which interactions with sodium chloride and other solutes influence nebulizer performance. In studies of the delivery of amiloride hydrochloride and trisodium uridine triphosphate (UTP), both used in the treatment of cystic fibrosis, an interaction occurred in which a precipitate of the two drugs was formed in the ratio 3 amiloride 1 UTP.45 The presence of sodium chloride suppressed the solubility of amiloride further by the common ion effect. 

Knowles MR, Church NL, Waltner WE, et al. A pilot study of aerosolized amiloride for the treatment of lung disease in cystic fibrosis. N Engl J Med 1990 322 1189-1194. 

Bennett WD, Olivier KN, Zeman KL, et al. Effect of uridine 5 -triphosphate plus amiloride on mucociliary clearance in adult cystic fibrosis. Am J Respir Crit Care Med 1996 153 1796-1801. 

Thomas 8HL, O Doherty MJ, Graham A, Page CJ, Nunan TO. Pulmonary deposition of nebulised amiloride in cystic fibrosis comparison of two nebulisers. Thorax 1991 46 717-721. 

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