Cysteine proteases inhibitors homologues

The N-terminal sequence of one peptide from the 35 kDa zone of H-gal-GP showed some homology to cathepsin B-like cysteine proteases. Molecular cloning has also identified a thrombospondin homologue associated with the diffusely staining region between zones A and B, a galectin associated with zone D (Newlands et al., 1999) and a low molecular weight (approximately 13 kDa) cysteine protease inhibitor, cystatin. 

Arabidopsis thaliana (mouse-ear cress) (Brassicaceae) Cysteine protease inhibitor (CPI) protein homologues (genes) (11-51 kDa proproteins) Cysteine protease inhibitor protein homologues [141- 146]... 

Solatium tuberosum (Solanaceae) [tuber] Potato Cysteine Protease Inhibitors (PCPIs) (20-25 kDa Kunitz PI homologues - for details see Table 12 ) Cysteine proteases (e.g. Papain, Cathepsins B, H L) - for details see Table 12 [185- 188]... 

Solanum Cysteine Protease Inhibitor (PCPI) (22 kDa) Solanum tuberosum (Solanaceae) [tuber] STI (KPI) homologue (CYSPR)... 

In the execution phase of apoptosis, caspase proteases are activated by various apoptotic stimuli. Caspases belong to the cysteine protease family and were originally identified as homologues of the ced- i (cell death abnormal) gene product (an executor of apoptosis in Caenorhabdi-tis elegans). Indeed, most caspases induce apoptosis if they are overexpressed in growing cells and cell death can be blocked by caspase-specific inhibitors. Therefore, caspases are accepted as executors for apoptosis in mammals and this pathway appears to be conserved between species. 

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