Cypholophus

In the tests conducted on 102 samples of 74 species, the following were positive Boehmeria caudata (2/3), B. cylimlrica (previously known) (3/3), Boehmeria sp., B. spicata, B. ulmi/olia, Coussapoa orthoneura, Coussapoa sp., Cypholophus friesianus, Cypholophus sp., Myrianlhus arbnreus, Parietaria pennsylvanica. 

Cypholophine (106) and O-acetylcypholophine (107) were isolated in 1970 by Hart et al. (157) from Cypholophus friesianus (K. Schum.) H. Winkl. (Urticaceae), a shrub growing in Australia and New Guinea. Spectral data and degradation products led to the proposal of structure 106 for cypholophine. This structure was confirmed by the following synthesis. 

Aphananthe philippinensis Planchon Boehmeria platyphylla Don Cypholophus decipiens H. Winkler C. friesianus (K. Schum.) H. Winkler Cypholophus sp. 

The pandemic nettle family, Urticaceae, was hardly known as a source of alkaloids until the isolation of the phenanthroquinolizidine base cryptopleurine (31) from two Boehmeria spp., together with certain others such as the seco-base, julandine (32), that appear to be biosynthetically related to it 47. The latter had not been recorded previously, but cryptopleurine was already known, having been obtained from a lauraceous plant referred to later apart from these examples, another genus of the Urticaceae, Cypholophus, produced cypholophine (33), a new type of imidazole alkaloid [48. ... 

Two new alkaloids, cypholophine (2 R = H) and O-acetylcypholophine (2 R = Ac), have been isolated from Cypholophus Jriesianus and their structures... 

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