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Cyclosporine hirsutism with

Cyclosporine reduces production of cytokines involved in T-cell activation and has direct effects on B cells, macrophages, bone, and cartilage cells. Its onset appears to be 1 to 3 months. Important toxicities at doses of 1 to 10 mg/kg/day include hypertension, hyperglycemia, nephrotoxicity, tremor, GI intolerance, hirsutism, and gingival hyperplasia. Cyclosporine should be reserved for patients refractory to or intolerant of other DMARDs. It should be avoided in patients with current or past malignancy, uncontrolled hypertension, renal dysfunction, immunodeficiency, low white blood cell or platelet counts, or elevated Ever function tests. [Pg.52]

Cyclosporine has significant nephrotoxicity, and its toxicity can be increased by drug interactions with diltiazem, potassium-sparing diuretics, and other drugs inhibiting CYP3A. Serum creatinine should be closely monitored. Other toxicities include hypertension, hyperkalemia, hepatotoxicity, gingival hyperplasia, and hirsutism. [Pg.807]

Adverse Effects. The primary problem associated with cyclosporine is nephrotoxicity, which can range from mild, asymptomatic cases to severe kidney dysfunction, which requires discontinuation of the drug.33,46 Hypertension is also a common adverse effect, especially when cyclosporine is used for prolonged periods.58 Other problems include neurotoxicity, gingival hyperplasia, hair growth (hirsutism), and increased infections. These problems, however, tend to... [Pg.595]

Toxicities are numerous and frequently include nephrotoxicity, hypertension, hyperglycemia, liver dysfunction, and hirsutism. A significant increase in the incidence of cholelithiasis has been observed in children treated with cyclosporine after heart transplantation. Cyclosporine causes very little bone marrow toxicity. While an increased incidence of lymphoma and other cancers (Kaposi s sarcoma, skin cancer) has been documented in transplant recipients receiving cyclosporine, other immunosuppressive agents may also predispose recipients to cancer. Some evidence suggests that tumors may arise after cyclosporine treatment because it induces TGF-3, which promotes tumor invasion and metastasis. [Pg.1339]

Toxicity The principal adverse reactions to cyclosporine therapy are renal dysfunction, tremor, hirsutism, hypertension, hyperhpidemia, and gum hyperplasia. Hyperuricemia may lead to worsening of gout, increased P-glycoprotein activity, and hypercholesterolemia. Nephrotoxicity occurs in the majority of patients treated and is the major indication for cessation or modification of therapy. Hypertension occurs in -50% of renal transplant and almost all cardiac transplant patients. Combined use of calcineurin inhibitors and glucocorticoids is particularly diabetogenic, although this apparently is more problematic in patients treated with tacrohmus see below). Especially at risk are obese patients, African American or Hispanic recipients, or those with family history of type 2 diabetes or obesity. Cyclosporine, as opposed to tacrolimus, is more hkely to produce elevations in low-density lipoprotein (LDL) cholesterol. [Pg.913]


See other pages where Cyclosporine hirsutism with is mentioned: [Pg.90]    [Pg.485]    [Pg.1402]    [Pg.430]   
See also in sourсe #XX -- [ Pg.1402 ]




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