Cyclopropaneacetic acids

Chemical Name Cyclopropaneacetic acid, l-((((lR)-l-(3-((lE)-2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(l-hydroxy-l-methylethyl)phenyl) propyl)thio)methyl)-, monosodium salt... 

Following the hydrolysis the methyl l-((((R)-(3-(2-(7-chloro-2-quinolinyl) ethenyl)phenyl)-3-(2-(2-hydroxy-2-propyl)phenyl)propyl)thio)methyl) cyclopropaneacetate with NaOH was obtained the free acid 4-((l(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(2-hydroxy-2-propyl)-phenyl)propyl) thio)methyl)cyclopropaneacetic acid or sodium l-(((l(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(2-hydroxy-2-propyl)phenyl)propyl)thio) methyl) cyclopropaneacetate. 

Keating and Skell" and later Laurent and Thomalla" have found that a similar mixture of products was obtained in the anodic oxidation of either cyclobutanecarboxylic acid, allylacetic or cyclopropaneacetic acid. They accounted for these results by a rapid equilibria among the carbocations initially formed. A similar observation is that in the anodic oxidation of the corresponding iodo reactants in acetonitrile N-(cyclopropylmethyl)acetamide was found in each product mixture". It is noteworthy that the same identity in products also holds for the chemical reactions of solvolysis and... 

Similarly, j8-alkenyl- -propiolactones 5 were reacted with 9-borabicyclo[3.3.1]nonane, followed by sodium methoxide to give cyclopropaneacetic acids 6 as cisjtrans mixtures in fair yield. ... 

Decenoic acid Me ester, in D-00068 2-Hexyl-1-cyclopropaneacetic acid, H-00221 2-Nonenoic acid Et ester, in N-00036... 

Merck Co., Inc. Process fm the preparation of l-(thiomethyl)-cyclopropaneacetic acid, US... 

In rats, rapidly oxid. In vitro, transamin. and decarbox. to methyl-ene-cyclopropaneacetate (6), which blocks fatty acid OC g oxid. in vitro tox. of hypoglycin prob.due to this metab. (7). 

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