Cyclopenta pyrene carcinogenicity

Rogan, E., E. Cavalieri, A. Munhall, and S. Salmasi. 1983. Synergistic effect of the environmental contaminants cyclopenta(cd)pyrene and benzo[a]pyrene in mouse skin carcinogenicity. Pages 1035-1046 in M. Cooke and A.J. Dennis (eds.). Polynuclear Aromatic Hydrocarbons Mechanisms, Methods and Metabolism. Battelle Press, Columbus, OH. 

The equivalent air-fuel-ratio also influences the PAH profile. The profile describes the mass relationship of the different PAH components. The portion of carcinogenic components of Epah drops with increasing X. In Fig. 3 the reduction of "Chrysene (consisting of Chrysene + Benzo(a)anthracene + Cyclopenta(cd)pyrene + Triphenylene) is illustrated for mixture leaning. Benzo(a)pyrene also drops from 3 % at X = 0,9 to approx. 2 % at X = 1,1. The non-carcinogenic component Pyrene is mainly the component which proportionally increases with increasing X. 

Arene oxides continue to excite interest because of their carcinogenic and mutagenic potential and a number of syntheses of such compounds have been reported during 1979. The synthesis of cyclopenta[cJ]pyrene 3,4-epoxides from the parent hydrocarbon has been achieved using a procedure which should be applicable to epoxidation of a range of other arenes (Scheme 16). Chrysene epoxides are available by essentially conventional syntheses. The synthesis of (+)- and (—)-naphthalene and anthracene 1,2-oxides has been described. The... 

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