Cyclohexylmagnesium chloride

Cyclohexyl chloride, 6, 24 Cyclohexylmagnesium bromide, 6, 20 Cyclohexylmagnesium chloride, 6, 24 3 Cyclohfxvi Propinf-i, 6, 26 Cyclopentanone, 5, 37 l Cystine, 5, 39... 

The Grignard reagent may be standardized by the general procedure described for cyclohexylmagnesium chloride 4... 

One limitation of this methodology is that unprotected terminal alkynes are incompatible with the strongly basic ethyl zinc reagents required for this reaction. Iivinghouse and coworkers found that a similar Ti(IV)tetra-aryloxide/cyclohexylmagnesium chloride system catalytically cycloisomer-ized dienes to methylenecyclopentanes 63 with the formation of some reduced product 64 (Eq. 8) [35]. 

Ketene dithioacetals. These useful synthetic intermediates can be prepared from Grignard reagents in a one-pot sequence (equation I). The method/ails with allylmagnesium bromide, and only low yields of ketene dithioacetals are obtained from cyclohexylmagnesium chloride and benzylmagnesium chloride (5 10%). 

Ally) ethers are selectively cleaved with titanium(lV) isopropoxide and commercially available Grignard reagents like /i-butyl- or cyclohexylmagnesium chloride [Scheme 4.229].432 Neither benzylidene acetals nor more highly substituted allylic ethers suffer under the reaction conditions. A mechanism for the reaction implicates formation of the titanacyclopropane intermediate 229.1 as the first step. Ligand exchange with an unsubstituted allyl ether affords intermediate 229.2. -Elimination to the allyltitanium(lV) alkoxide 2293 followed by hydrolysis returns the deprotected alcohol. The reaction closely resembles an earlier method based on zirconium.433... 

Derivation By Grignard reaction of silicon tetrachloride and cyclohexylmagnesium chloride. 

Cyclohexyl isocyanate Cyclohexylisopropylamine Cyclohexyl isothiocyanate Cyclohexylmagnesium chloride Cyclohexyl methacrylate Cyclohexylmethylamine... 

A cobalt-catalysed insertion of 1-alkene, 2-alkene, and styrene into the ortho C-H bond of benzamides, such as (94), has been attained by using l,3-dimethyl-3,4,5,6-tetrahydro-2(l/7)-pyrimidone (DMPU) as a key ligand, and cyclohexylmagnesium chloride. The reaction proceeds at 25 °C to afford the < rt/io-alkylated product (95) selectively. ... 

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