3-cyclohexyl thiophene

Figure 13.17 Relation between the structure of copolymers of 3-cyclohexyl thiophene and 3-w-hexyl thiophene, and the quantum efficiency of light-emitting didoes based on...

Figure 13.18 Photoluminescence spectra of copolymers synthesised using ratios of 3-n-hexyl thiophene 3-cyclohexyl thiophene (I) 1 9, (II) 2 3, (III) 1 1, (IV) 9 1...

V. Saxena and V.S. Shirodkar, A study of light-emitting diodes constructed with copolymers having cyclohexyl thiophene and hexyl thiophene units, J. Appl. Polym. Sci., 77 1051-1055, 2000. 

Chemical Name 0i-[4-(Diethylamino)cyclohexyl] -Q -2-thienyl-2-thiophene-methanol Common Name —... 

Fig. 21 Microwave-promoted multicomponent synthesis of polysubstituted thiophenes on solid-phase. Reagents and conditions a RCOCH2R (R = H, Me, Et, Bn R = Me, i-Bu, i-Pn, Ph, Bn, cyclohexyl), Ss, DBU, toluene, MW 120 °C, 20 min, closed vessel, 100% b R"COCl (R" = Me, Pr, Ph or COOMe), diisopropylethylamine, toluene, MW 100 °C, 10 min, closed vessel c TEA, H2O, CH2CI2, rt, 2h...

Cyclohexyl carbamic acid 3 -carbamoyl-biphenil-3-y 1-ester (l-Methyl-4-(2-chloro-4-hydroxyphenylthio)-piperidine (R)-N-(l-azabicyclo[2.2.2]oct-3-yl)(5-(2-pyridyl)thiophene-2-carboxamide)... 

Cyclohexyl prostaglandin analogs derivatized with 3-chloro-benzo[b]thiophen-2-yl, (V), prepared by Old (5) were effective as EP4 agonists and used in the treatment and management of glaucoma. 

In comparison with that of compound 175, the energy barriers toward coplanar conformations increase, and the equilibrium torsion angle becomes larger in the torsion potential curve of compound 181, around 85°. The thiophene rings are even more twisted by cyclohexyl groups than by hexyl groups. 

Thiophen 2-[l(bzw. 4)-Chlor-cyclohexyl]-4-methyl- E6a, 208 (C1-CH2-CRCI-CH2-CO-R + P4S10)... 

Some Dewar tetrakis(trifluoromethyl)pyrroles react as dienophiles. Their reactivities depend on the substituent on the nitrogen atom. A few reactions are shown in Table I, with the results of the Dewar thiophene analog for comparison. Interestingly, N-unsubstituted Dewar pyrrole is the most and the N-cyclohexyl compound the least reactive of the three. These results seem to indicate a steric requirement in the transition states. 

The synthesis of thiophenes by a MCR on water was recently studied by Moghaddam and coworkers [75]. In this study, 3-morpholino-3-thiooxopropanenitrile (127), cyclohexyl isocyanide (128), and a-haloketones 129 in water were heated at 60°C to afford the corresponding highly functionalized thiophenes 130 in good yields (59-74%) (Scheme 11.25). 

The reaction starts with the addition of 3-morpholino-3-thiooxopropanenitiile 127 to cyclohexyl isocyanide 128. Next, the nucleophilic addition of sulfur in compound 131 to a-haloketones 129, followed by the base-catalyzed cycliza-tion in compound 132 and elimination of cyclohexylamine, gives the corresponding thiophenes 130 (Scheme 11.26). 

Taking together the biological activity, the physicochemical and toxicological data, N-Cyclohexyl-benzo-thiophen-2-carboxamid-S,S-dioxid was the best candidate for the use in waterbased emulsion paints and was developed as Preventol TP OC 3082 and TP OC 3061 by Bayer. As can be seen from Table 2, it has a broad fungicidal and a slight algicidal activity. 

An investigation concerning the /p5o-substitution of a nitro group in 2-nitrothiophenes demonstrated that 1-adamantyl radical (Ad) and cyclohexyl radical (Cyclohex ) selectively attack the /p5o-positions of thiophenes bearing... 

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