Cyclohepta pyrrol

USP4382088). On the cyclization of Af-(7-oxocycloheptatrien-l-yl)-aminomethylenemalonate (880, R = H), cyclohepta[6]pyrrole-3-carbox-ylate (882) was isolated as a byproduct (83USP4381304). 

Recently, cyclohepta[6]pyrrol-4-one derivatives were obtained as byproducts in the 1-azaazulene synthesis from 2-chlorotropone and 1-(diphenylphosphinyl)azaallyl anions [93H(36)2247],... 

Methylcyclohexanone and suberone (cycloheptanone) oximes correspondingly give 7-methyl-4,5,6,7-tetrahydroindole (33, yield 70%), its N-vinyl derivative [34, yield 80% (75MI1)], and 4,5,6,7,8-pentahydro-l//-cyclohepta[6]-pyrrole [35, yield 79% (76MIP1 80KGS1299)] (Table XIX). 

Cyclohepta[c]pyrrol-2-ium salt, 1,3,5,7-tetramethyl-2-phenyl-, use as oxidizing agent, 60, 110... 

Goudie, A. C., Rosenberg, H. E., Ward, R. W. 4,5,8,9-Tetrahydro-8-methyl-9-oxothieno[3, 2 5,6]cyclohepta[1,2-b]pyrrole-7-acetic acid. A new anti-inflammatory/analgesic agent. J. Heterocycl. Chem. 1983, 20,1027-1030. 

Use of a ring-expansion reaction for the synthesis of l,5-methano-4-benzazonin-12-ones and derivatives of benzo[3,4]cyclohepta[1.2-6]pyrrole., 7. Chem. Res. (M), 2024. 1989. 

With trifluoroacetic acid as catalyst, the cyclohepta[6]pyrrole (54.2) is cyclized into the diazepinone (54.4) in 96% yield. 

Cycioaddition of cyclohepta[6]pyrrole to DMAD in boiling benzene gives a product which contains two molecules of DMAD and a minor product which contains one DMAD molecule. CycIohept[[Pg.695]

Cyclohepta[i]pyrrol-2-ylhydrazines (71) react with triethylorthoformate to give triazoles (72), and the 3-oxo, 3-thioxo, and 3-amino derivatives were similarly prepared by treating (71) with carbonyldiimidazole, carbon disulfide, or cyanogen bromide, respectively <85JCR(S)363>. A similar cyclization of the cyclic amidrazone (73) with triethylorthoformate gave the triazoloisoindole (74) (Scheme 11) <85UKZ94>. 

An autorecyling process is suggested to account for the greater than 100% yields obtained for the oxidation of some amines by 6,9-disubstituted cyclohepta[Z)]pyrimido[5,4-d]pyrrole-8(6//),10(9i/)-dione derivatives such as... 

C02Me, etc.) have been prepared by bis-condensations between the appropriate pyrrole bis-aldehyde and substituted acetone l,3-dimethyl-2/f-cyclohepta[c]pyrrol-6-one (148 R = H, R = R = Me, X = H) was then converted into 6-ethoxy-l,3-dimethyl-2-aza-azulene, ... 

The chlorine at C-8 in (27 R = H) and in (27 R = Cl) has been replaced with a variety of N-, 0-, and S-containing nucleophiles the use of p-thiocresol gives substitution of both chlorine substituents. A closely related compound, 2-chloro-3-ethoxycarbonyl-cyclohepta[f>]pyrrole, with enolate anions gives a variety of substitution and addition products, dependent upon the reaction conditions. ... 

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