Cyclodextrin periodate oxidation

The cleavage of the ring of beta-cyclodextrin was accomplished by periodate oxidation. The kinetics of the oxidation of cyclodextrins with periodate have been studied by French et al. (10). During our work the Smith-degradation process was somewhat modified as the polyalcohol, obtained after the reduction, was converted into acetylated-, methylated and tosylated analogues. 

The cleavage of the ring of beta-cyclodextrin (Fig. 1) with periodate proceeds by splitting of the bond between the C-2 and C-3 atoms of each glucose unit connected with 1-4 linkages, no formaldehyde or formic acid is produced during the oxidation and a periodate consumption of 1 mol per glucopyra-nosyl moiety is measured. 

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