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Cyclo-oxygenase pathway

Arachidonic acid is of particular importance, being the initial compound for eicosanoid biosynthesis. Prostaglandins, prostacyclins and thromboxanes are synthesized from the eicosanoids via the cyclo-oxygenase pathway. The important mediators of inflammation — such as leukotrienes and leukotetraenes — are synthesized via the lipoxygenase pathway, (s. fig. 3.10)... [Pg.44]

Kremer JM. N-3 fatty acid supplements in rheumatoid arthritis. Am J Clin Nutr 2000 71 349s-351s. Lacroix S, Rivest S. Role of cyclo-oxygenase pathways in the stimulatory influence of immune challenge on... [Pg.417]

The synthesis of eicosanoids begins with arachidonic acid (C20 4 n-6 fatty acid) which is component part of cell membranes. The synthetic pathway is outlined in Figure 4.8. A key enzyme in this process is cyclo-oxygenase (COX) which occurs in two... [Pg.94]

Complement classical pathway inhibition. Ethyl acetate and methanol extracts of the fresh leaf were active on red blood cells, IC50 greater than 7.7 pg/mL and greater than 5.8 pg/mL, respectively " ". Cyclo-oxygenase inhibition. Essential oil of the unripe fruit, at a concentration of 100 pg/mL, produced weak activity on platelets " . [Pg.384]

Third, Berg et al. showed that the 5-HT2A receptor induces CaM-dependent increases in cAMP formation in A1A1 cells (201). Fourth, a CaM-dependent pathway is involved in 5-HT2A receptor-induced cyclo-oxygenase 2 mRNA expression in renal mesangial cells (202,203). [Pg.161]

WilUngale HL, Gardiner NJ, McLymont N, Giblett S, Grubb BD (1997) Prostanoids synthesized by cyclo-oxygenase isoforms in rat spinal cord and their contribution to the development of neuronal hyperexcitability. Br J Pharmacol 122 1593-1604 Willis WD Jr (1988) Dorsal horn neurophysiology of pain. Ann N Y Acad Sci 531 76-89 Willis WD, Westlund KN (1997) Neuroanatomy of the pain system and of the pathways that modulate pain. J CUn Neurophysiol 14 2-31... [Pg.531]

Many of the biological actions of essential fatty acids are the result of their metabolic products, the eicosanoids. These are oxidized derivatives of AA and include prostaglandins and thromboxanes that are formed via the cyclo-oxygenase (COX) pathway, as well as hydroxy fatty acids and leukotrienes that arise by means of the lipoxygenase pathway. Another series of AA-derived products, the epoxy fatty acids, are produced by the cytochrome P450 epoxygenase pathway. The AA that serves as precursor for these reactions... [Pg.241]

See other pages where Cyclo-oxygenase pathway is mentioned: [Pg.87]    [Pg.2679]    [Pg.205]    [Pg.96]    [Pg.363]    [Pg.20]    [Pg.28]    [Pg.34]    [Pg.82]    [Pg.130]    [Pg.71]    [Pg.81]    [Pg.87]    [Pg.2679]    [Pg.205]    [Pg.96]    [Pg.363]    [Pg.20]    [Pg.28]    [Pg.34]    [Pg.82]    [Pg.130]    [Pg.71]    [Pg.81]    [Pg.169]    [Pg.456]    [Pg.934]    [Pg.935]    [Pg.259]    [Pg.2]    [Pg.230]    [Pg.465]    [Pg.593]    [Pg.265]    [Pg.162]    [Pg.462]    [Pg.259]    [Pg.134]    [Pg.152]    [Pg.169]    [Pg.99]    [Pg.132]    [Pg.200]    [Pg.484]    [Pg.485]    [Pg.532]    [Pg.556]    [Pg.583]    [Pg.819]    [Pg.153]    [Pg.13]    [Pg.272]    [Pg.378]    [Pg.290]   
See also in sourсe #XX -- [ Pg.206 ]



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