Enkephalins cyclic

DiMaio J, Schiller PW. A cyclic enkephalin analog with high in vitro opiate activity. Proc Natl Acad Sci USA 1980 77 7162-7166. 

DiMaio J, Nguyen TM-D, Lemieux C, Schiller PW. Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogs effect of conformational constraints on opiate receptor selectivity. J Med Chem 1982 25 1432-1438. 

Development of Cyclic Enkephalin Analogs with High Receptor SpecTn city--------------- ---------------------------------... 

Fig. 3. Structure of a cyclic enkephalin analog designed by Schiller and co-workers (DiMaio el al., 1982).

Conformational Free Energies of Cyclic Enkephalin Analogs. ... 

Delta-selective enkephalin analogs were prepared by cyclizationthrough disulfide bond formation. (Cyclic enkephalin analogs containing D- or L-Cys residues in positions 2 and 5... 

As in the case of cyclic enkephalin analogs, conformationally constrained 6-selective peptides with the sequence Tyr-o-X-Phe were also prepared by cyclization through a disulfide bond. Cyclization between o-Cys in position 2 and D-Pen in position 4 yielded the tetrapep-tide derivative Tyr-cyc/o[D-Cys-Phe-D-Pen]-OH (JOM-13, 249), which contains a fairly... 

K. and Yamamura, H.I. (1983) Conformationally constrained cyclic enkephalin analogs with pronounced delta opioid receptor agonist selectivity. Life Sci. 32 2565-2569. 

Hassan, M. and Goodman, M. (1986) Computer simulations of cyclic enkephalin analogues. Biochem. 25 7596-7606. 

Malicka, J., Groth, M., Czaplewski, C., Wiczk, W. and Liwo, A. (2002) Conformational studies of cyclic enkephalin analogues with L-or D-proline in position 3. Biopolym. 63 217-231. 

Sequential catalytic hydrogenation of the imine bond followed by hydrogenoly-sis of the resultant yV-diphenylmethylamine is an alternative method of deprotection which was used in a solid-phase synthesis of O-glycosyl cyclic Enkephalin analogues [Scheme 8.236]. Note the comprehensive deprotection of 4 benzyl ethers, a diphenylmethyl ester, and an N-diphenylmethyleneamine in a single operation. iV-Diphenylmethyleneamine derivatives of serine have also been applied to the synthesis of Sphingosines. ... 

R 64 J. Malicka, C. Czaplewski, M. Groth, W. Wiczk, S. Oldziej, L. Lan-kiewicz, J. Ciarkowski and A. Li wo, Use of NMR and Fluorescence Spectroscopy as well as Theoretical Conformational Analysis in Conformation-Activity Studies of Cyclic Enkephalin Analogues , p. 123 R 65 A. Naito and K. Nishimura, Conformational Analysis of Opioid Peptides in the Solid State and the Membrane Environments by NMR Spectroscopy , p. 135... 

Sdifliee P. W., 1983, Fhioresceoee study on the eonfomatitm of a cyclic enkephalin analog in aqueous eteution. Biodum Biophys. Res. CcmmiM. 114 268-274. 

Table 6. Cyclic enkephalins. Assays for delta (6) vs. mu (pi) receptor specificity...

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