Diphenylmethyl ester

Diphenylmethyl esters are similar in acid lability to r-butyl esters and can be cleaved by acidic hydrolysis from 5-containing peptides that poison hydrogenolysis catalysts. 

Bis(o-nitrophenyl)methyl esters are formed and cleaved by the same methods used for diphenylmethyl esters. They can also be cleaved by irradiation hv = 320 nm, dioxane, THE,..., 1-24 h, quant, yield). ... 

M HCl, EtOAc, 25°, 30 min, 96% yield. With MeOH as the solvent, a diphenylmethyl ester is not affected. The combination of HCl/EtOAc leaves TBDMS and TBDPS ethers and t-butyl esters and nonphenolic ethers intact during BOC cleavage, but 5 -BOC derivatives are cleaved. 

C,(jH22N203 7239-08-5) see Ttopicamide [6J -[6a,7p(Z)J)-3-[(acetyloxy)methyl]-7-[[2-furanyl(wieth-oxyitnino)acetyl]amino]-8-oxo 5-thia-l-azabicyclo[4.2.0]-oct>2>ene>2-carboxylic acid diphenylmethyl ester... 

C29H32N2O4 57227-08-4) see Tiropramide (6ff-cix)-7-(benzoylamino)-3-(chIoromethyl)-7-inethoxy-8-oxo-5-oxa-l-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester... 

C,3H,2S 4237-48-8) see Adrafinil [6/ -(6a,7a)]-7-[[3-(diphenylmethoxy)-2- 4-hydroxyphe-nyl)-l,3-dioxopropyl]amino]-7-methoxy-3-[[(l-methyl-lff-tetrazol-5-yl)thio]methyl]-8-oxo-5-oxa-l-azabicyclo[4.2.0]-oct-2-ene-2-carboxylic acid diphenylmethyl ester (C4 H4,N(,09S) see Latamoxef diphenylmethyl 7-aminocephalosporanate (C23H22N2O5S 27266-61-1) see Cefbuperazone Cefoxitin Cefuroxime... 

Oxa-1 -azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 8-oxo-7-(phenylacetamido)-3-(5-tetrazolylthiomethyl)-, diphenylmethyl ester X-ray, 7, 349 (B-82MI51206)... 

Curini, M. Rosati, O. Pisani, E. Preparation of diphenylmethyl esters by oxone oxidation of benzophenone hydrazone. Tetrahedron Lett. 1997, 38, 1239-1240. 

C] H, )N08 128289-78-1) see Moexipril [6/t- 6a,7[)(f( )]]-7- 5-(benzoylamino)-6-(diplienyl-methoxy)-l,6-dioxohexyl]amino]-3-(chloromethyl)-8-oxo-S-thia-l-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester (C47H42C1N,07S) see Cefixime [6W- 6(i,7p(/f )]]-7- 5-(benzoylamino)-6-(diphenyl-methoxy)-l,6-dioxohexyl]amino]-3 -ethenyl-8-oxo-5-thia-... 

---