Cyclic AMP regulation

Walaas, S.I., Aswad, D.W., Greengard, P. A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions. Nature. 301 69, 1983. 

Caporaso, G.L., Bibb, J.A., Snyder, G.L. et al. Drugs of abuse modulate the phosphorylation of ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in the basal ganglia. Neuropharmacology. 39 1637, 2000. 

Hemmings HC, Jr, Girault JA, Williams KR, LoPresti MB, Greengard P (1989) ARPP-21, a cyclic AMP-regulated phosphoprotein (Mr = 21,000) enriched in dopamine-innervated brain regions. Amino acid sequence of the site phosphorylated by cyclic AMP in intact cells and kinetic studies of its phosphorylation in vitro. J Biol Chem 264 7726-7733. 

VAN WlLLIGEN G, AKKERMAN JWN. Protein kinase C aixl cyclic AMP regulate reversible exposure of binding sites for fibrinogen on the glycc otein llb/IIIa complex of human platelets. Biodiem J2T3 115-121, 1991. 

In the course of studies designed to elucidate the mechanism by which cyclic AMP regulates phosphorylase activation and glycogenolysis in... 

A compound SQ 22536 (4), has been reported to inhibit adenyl cyclase and lower cyclic AMP levels. This compound does not aggregate platelets, but does increase platelet aggregation when challenged with an aggregating agent.This supports the theory that cyclic AMP regulates platelet aggregation. ... 

Walaas SI, Naim AC, Greengard P (1986) PCPP-260, a purkinje cell-specific cyclic AMP-regulated membrane phosphoprotein of M, 260,000. J. Neurosci, 6, 954-961. 

Mann, S.K.O. R.A. Firtel. 1987. Cyclic AMP regulation of early gene expression in Dictyostelium discoideum Mediation via the cell surface cyclic AMP receptor. Mol. Cell. Biol. 7 458-69. 

Perlman, R. L., Crombrugghe, B. de, Pastan, I. Cyclic AMP regulates catabolite and transient repression in E. coli. Nature (Lond.) 223, 810-812 (1969). 

Draw the structure of cyclic adenosine monophosphate (cAMP), a messenger involved in the regulation of glucose production in the body. Cyclic AMP has a phosphate ring connecting the 3 and 5 hydroxyl groups on adenosine. 

Protein kinase A (PKA) is a cyclic AMP-dependent protein kinase, a member of a family of protein kinases that are activated by binding of cAMP to their two regulatory subunits, which results in the release of two active catalytic subunits. Targets of PKA include L-type calcium channels (the relevant subunit and site of phosphorylation is still uncertain), phospholam-ban (the regulator of the sarcoplasmic calcium ATPase, SERCA) and key enzymes of glucose and lipid metabolism. 

Cyclic-AMP Response Element Binding Protein Cyclic GMP-dependent Protein Kinase Cyclic GMP-regulated Phosphodiesterases Cyclic Guanosine Monophosphate (Cyclic GMP cGMP)... 

MLCK itself is phosphorylated by cyclic-AMP activated protein kinase, (protein kinase A) and cyclic-GMP activated protein kinase, (protein kinase G). Protein kinase A will phosphorylate MLCK at two sites and protein kinase G at one in some cases and two in others. These differences seem to be important in how the individual smooth muscle cells are regulated. 

Montminy M Transcriptional regulation by cyclic AMP. Annu Rev Biochem 1997 66 807... 

The properties of a particular molecule are due to the types and number of atoms it contains and how those atoms are arranged in space. Caffeine is a stimulant because it has the same shape as one part of cyclic adenosine monophosphate (cyclic AMP), a molecule that helps to regulate the supply of energy in the brain. When caffeine is absorbed into the blood and carried to the brain, it binds to an enzyme that normally controls the supply of cyclic AMP. As a result, the enzyme can no longer bind cyclic AMP, the brain s supply of this energy-regulating molecule is increased, and we feel stimulated. 

MacKenzie, R. S., Melan, M. A., Passey, D. K. Witt-Enderby, P. A. (2002). Dual coupling of MTi and MT2 melatonin receptors to cyclic AMP and phosphoinositide signal transduction cascades and their regulation following melatonin exposure. Biochem. Pharmacol. 63, 587-95. 

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