Lincomycin Cyclamates

The improved thermal stability of naproxen and tolmetin as a result of formation ofthe choline salt has already been noted. Stability studies of lincomycin as its hydrochloride or cyclamate salt revealed that the cyclamate counterion provided an enhanced thermal stability to the antibiotic without compromising the aqueous solubility (Neville and Ethier, 1971 Neville et al., 1971). 

Neville, G. A. J. C. Ethier, N. F. H. Bright, and R. H. Lake. 1971. Characterization of some lincomycin and cyclamate salts by thermal analysis and infrared spectrosAc soc. Off. Anal. Cheifi4 1200-1210. 

The serum levels of lincomycin are markedly reduced (by up to two-thirds) if taken in the presence of food, but clindamycin is not significantly affected. Cyclamate sweeteners can also reduce the absorption of lincomycin. 

Sodium cyclamate, an artificial sweetener found in diet foods, drinks and some pharmaceuticals, can also markedly reduce the absorption of lincomycin. The AUC of lincomycin 500 mg was reduced by about 75% by 1 Molar equivalent of sodium cyciamate (said to be an amount equal to only part of a bottle of diet drink, but exact quantity not stated). ... 

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