CuZn Superoxide Dismutases SOD

Water molecules are depicted by W and Xs show the positions of the Cu and Zn ions. 

A recent structural determination of the bovine enzyme at 1.7 A resolution suggests that the Cu(l)/Cu(ll) transition, along with their related coordination changes, is modulated by a protein loop that lines the active site cavity [15]. Again, possible photoreduction resulting from exposure to X-rays has been considered and (possibly) ruled out by examination of electron density maps and temperature factors corresponding to atoms at the active site. 

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Francis 1W, Hosier BA, Brown RHJ, Fishman PS (1995) CuZn superoxide dismutase (SOD-l) tetanus toxin fragment C hybrid protein for targeted delivery of SOD-1 to neuronal cells. J Biol Chem 270 15434 12... 

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