2- cthyl

Experimental evidence, obtained in protonation (3,6), acylation (1,4), and alkylation (1,4,7-9) reactions, always indicates a concurrence between electrophilic attack on the nitrogen atom and the -carbon atom in the enamine. Concerning the nucleophilic reactivity of the j3-carbon atom in enamines, Opitz and Griesinger (10) observed, in a study of salt formation, the following series of reactivities of the amine and carbonyl components pyrrolidine and hexamethylene imine s> piperidine > morpholine > cthyl-butylamine cyclopentanone s> cycloheptanone cyclooctanone > cyclohexanone monosubstituted acetaldehyde > disubstituted acetaldehyde. 

The action of potassium hydroxide on a solution of 2-( -phenyI-cthyl)-3-isopropyloxazirane (20) in glycol solution gives a mixture of acetophenone (0.25 mole), isobutyraldehyde (0.57 mole), and ammonia (0.92 mole). ... 

A solution of 4.5 g (19.9 mmol) 4-(fm-butyldimethylsilyloxy)-2-cyclohexenone and 452 mg (1 mmol) of mercury(II) iodide is stirred at r.t. for 15 min and then cooled to — 78 °C. 5.03 g (24.8 mmol) of 1-ethoxy-1-(tm-bulyl(iimethylsilyloxy)ethene are added dropwise during 15 min. The mixture is stirred at — 78 °C for 2 h, quenched with 302 mg (3 mmol) of triethylamine and allowed to warm to r.t. The mixture is filtered through a short (3 cm) column of silica gel (deactivated with a 5% triethylamine solution in hexane/ethyl acetate, 10 1) eluting with hexane/ethyl acetate (10 1) and concentrated in vacuo. Purification of the crude material by flash chromatography (silica gel, hcxanc/cthyl acetate 30 1) gave the adduct as a colorless oil yield 7.98 g (18.7 mmol, 94%) d.r. (cisjtrans) 95.2 4.8. 

A solution of 0.858 g (5.5 mmol) of 4-(1-methyl-l-butenyl)morpholine and 0.75 g (5.0 mmol) of ( )-(2-ni-troethenyl)benzene in 10 mL of diethyl ether is kept at r.t. for 4d. The solution is then evaporated and treated with a mixture of 13 mL of ethanol and 15 mL of 10% aq hydrochloric acid for 1 h at 25 C. The solution is extracted with CH2C12 and the organic phase is washed with aq Nall CO, then with water and dried over MgSO . Evaporation gives 1.04 g of an oil which is purified by column chromatography (silica gel. hexanc/cthyl acetate 10 1) to give the pure title compound as an oil yield 0.90g (77%). The diastereomeric ratio is determined by HPLC (methanol/water 4 1, reverse phase RP8) to be 93 7. 

Antimonate, hexafluoro-, 3, 276 Antimonate, tris(cthyl dithioearbonate)-electron pair, 1, 37 Antimonates, 3, 265 Antimonic acids, 3, 265 Antimony, 3, 237-294 biology, 3,277 carcinogenicity, 3, 278 coordination number, 3, 256 determination... 

Benzene, 1 ethyl 4 (l-methylethyl)- [Benzene, l-cthyl-4 isopropyl-], 55, 10 BENZENE, 1, l -ethylidenebis [Ethane, 1,1-diphenyl], 55, 7... 

CN 2-l(2-ammoethoxy)methyl]-4-(2-chlorophenyl)-l.4-dihydro-6-rtiethyl-3,5-pyridinedicarboxylic acid 3-cthyl 5-methyl e.ster... 

CN 1 -methyl-1 -[ 1 -methyl-2-oxo-2-( 10//-phenothiazin-10-yl)cthyl]pyrrolidinium bromide... 

C2 H 4(,04 63042-28-4) see Estradiol valerate 4,9,1 l-estratrien-3,17-dione 3-oxime (CisHiiNOi 846-56-0) see Norgestrienone (17P)-estra-l,3,5(10)-triene-3,17-diol 3-[bis(2-chloro-cthyl)carbamate]... 

Cyclization of 1 -[.V- 2.2-bis(/ t )-butyloxycarbonyl)cthyl -./V-mcthylamino]-5,6,7,8-tetrafluoro-4-oxol, 4-dihydroquin-... 

Compound 7-ethyl-7-methyl-3-phenyl-2,3,4,9-tetrahydropyrimido[l,2-tf][l,3,5]triazine-6,8-dione 71 <2002JHC663> was prepared by the one-pot condensation reaction of 6-amino-3-cthyl-3-mcthyl-5//-pyndinc-2,4-dionc 70 with aromatic amines and formaldehyde (Equation 3). 

For the preparation of N- 2-(methoxyphenyl)cthyl ]-4-mcthylbcn-zenesulfonamide (1) from Ameba resins A and Ba-Bd, 100 mg (0.089 mmol) Ameba resin A was added to a glass peptide reaction vessel, suspended in 3.0 mL 1,2-dichloroethane (DCE note 2), and treated with 26 pL (0.18 mmol, 2.0 Eq.) 2-(4-methoxy-phenyl)ethylamine (note 2) and 38 mg (0.178 mmol, 2.0 Eq.) sodium triacetoxyborohydride (note 2). The suspension was shaken for 1 h treated with 5 mL MeOH filtered on a glass frit and washed with DCM (2x5 mL), DMF (2x5 mL), MeOH (2 x 5 mL), and DCM (2x5 mL). The resin was dried under vacuum (0.5 torr) at room temperature overnight. The resin was suspended in 1.5 mL DCM, treated with 155 pL (0.89 mmol, 10.0 Eq.) N,N-diisopropylethylamine (note 2) and 85 mg (0.445 mmol, 5.0 Eq.) p-toluenesulfonyl chloride (note 2), and shaken for 3.5 h. The reaction mixture was filtered on a glass frit, washed with DCM (2 x 5 mL), DMF (2x5 mL), MeOH (2x5 mL), and DCM (2 x 5 mL), and dried under vacuum (0.5 torr) at room temperature for 2h. The resin was treated with 2.5 mL of a solution of 5% trifluoroacetic acid (note 2) in DCM, shaken for 15 min, filtered on a glass frit, and washed with DCM (3x5 mL). The combined filtrate and washings were concentrated and dried under vacuum (0.5 torr) at room temperature overnight to afford 18.0 mg (66%) N- [2-(methoxyphenyl)ethyl] -4-methylbenzenesulfonamide (1). 

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