Crystallographical continuity

Preparation method (Stearic acid Tsp = 293 K) Crystallographical distortion, Dial /% Crystallographical continuity, Liat / nm... 

Thanks are due to the excellent practical work of a large number of graduate students in our research project. The X-ray crystallographers, Drs. S. W. Lee and S. Cho, are thanked for their continued interest in our studies. The BK-21 project (J. Ko), administered by the Ministry of Education, Korea, is thanked for financial support. 

As might be expected, the literature associated with studies of polymorphism and solvatomorphism has grown in proportion to the interest in the field. As a result, an annual review of the area has been initiated, and will be continued in succeeding volumes in the Profiles series. The citations in this article are drawn primarily from the major pharmaceutical and crystallographic journals, and therefore are not represented to be comprehensive. However, they should represent the bulk of work that was conducted with pharmaceutical interest in mind. 

Successive H-bond urea self-assembly of 4 and sol-gel transcription steps yield preferential conduction pathways within the hybrid membrane materials. Crystallographic, microscopic and transport data confirm the formation of self-organized molecular channels transcribed in solid dense thin-layer membranes. The ionic transport across the organized domains illustrates the power of the supramolecular approach for the design of continual hydrophilic transport devices in hybrid membrane materials by self-organization (Figure 10.8) [42-44]. 

Cyclic ureas incorporating a 1,3-diazepinone skeleton continue to be of pharmacological interest. The Ai V-disubstituted system 89 has been prepared and shown to be a potent inhibitor of factor Xa in vitro and to have an improved pharmacokinetic profile in the rabbit. The binding model for this series of compounds was confirmed by an X-ray crystallographic analysis of one analogue in the series <00BMCL301>. 

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