Crystallographic Study of Cyclodextrins and Their Inclusion Complexes

Crystallographic Study of Cyclodextrins and Their Inclusion Complexes 

The development of the structural study of CyDs in the last century has been summarized in several reviews [1-7]. In 1942, the crystallographic method was first applied to CyDs to determine molecular weight [8j. James et al. proposed a packing structure [9] for several crystalline complexes of a-CyD with small guest molecules in 1959. Preliminary crystallographic data of y -CyD complexes with benzene derivatives were reported in 1968 [10]. The crystal structure first solved by X-ray analysis in 1965 was that of the a-CyD complex with potassium acetate [11]. Structures of two other well-known CyDs, fi-CyD [12] and y-CyD [13, 14], were determined in 1976 and 1980, respectively. An up-to-date list of crystal structures determined by X-ray and/or neutron diffraction is collected in the Cambridge Crystallographic Database (http //www.ccdc.cam.ac.uk/). 

Cyclodextrins and Their Complexes. Edited by Helena Dodziuk Copyright 2006 WILEY-VCH Veriag GmbH Co. KGaA, Weinheim ISBN 3-527-31280-3 

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I 7 Crystallographic Study of Cyclodextrins and Their Inclusion Complexes... 

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