Biological Macromolecule Crystallization Database

GiUiland, G. L., Tung, M. and Ladner, J. E. (2002). The Biological Macromolecule Crystallization Database procedures and strategies. Acta Crystallogr. D 58,916-920. 

The process of crystallization is still largely a process of trial and error, but in an attempt to formulate general rules, the cumulative experiences of X-ray crystallographers are being compiled into online databases such as the Marseille Protein Crystallization Database (14) and the Biological Macromolecule Crystallization Database (15). These and similar databases will provide useful starting points in crystallization trials and may greatly accelerate the process. 

Gilliland GL, Tung M, Blakeslee DM, Ladner JE. Biological macromolecule crystallization database, version-3.0 - New features, data and the NASA archive for protein crystal-growth data. Acta Cryst. D-Biol. Cryst. 1994 50 408-413. 

G. L.Gilliland, M. Tung, D. M. Blakeslee, and J. Ladner, Biological Macromolecule Crystallization Database (BMCD), available online at http /A[Pg.496]

Gilliland, G. L. A biological macromolecule crystallization database a basis for a crystallization strategy. Crystal Growth 90, 51-59 (1988). 

Tel. 301-975-2208, fax 301-926-0416, e-mail rdj3 enh.nist.gov Thermodynamic data for almost 5000 gas phase compounds. Estimation of struaures drawn into program using Benson s additivity rules. IVTANTHERMO database with enthalpies of formation and other thermodynamic properties for 2300 substances. NIST/NASA/CARB Biological Macromolecule Crystallization Database with crystal growth conditions. PCs. 

Biological Macromolecule Crystallization Database (BMCD) The Biological Macromolecule Crystallization Database (BMCD) contains crystal data and the crystallization conditions, which have been compiled from literature. These include proteins, protein.protein complexes, nucleic acid, nucleic acid nucleic acid complexes, protein nucleic acid complexes, and viruses. 

Biological Macromolecule Crystallization Database and the NASA Archive for Protein http //ibm4.carb.nist.gov 4400/... 

Biological Macromolecule Crystallization xpdb.nist.gov 8060/BMCD4/index.faces Database BRENDA... 

In fact, a tremendous amount of information is available on the structures of biological macromolecules descriptions of structures of proteins and nucleic acids make up major portions of modern textbooks in biochemistry and molecular biology. The Protein Data Bank and the Nucleic Acid Database are online archives that contain sequence and structural data on thousands of specific molecules and complexes of molecules. This structural information comes from in vitro experiments, with structures inferred from the x-ray diffraction patterns of crystallized molecules, spectroscopic measurements using multi-dimensional nuclear magnetic resonance, and a host of other methodologies. 

Structural data are stored in, and can be accessed from, three primary databases which are continually updated. Data for organic and metal-organic compounds and boranes are compiled by the Cambridge Structural Database (www.ccdc. cam.ac.uk), while crystallographic data for purely inorganic compounds (e.g. metal and non-metal halides and oxides) are deposited in the Inorganic Crystal Structure Database (www.fiz-karlsruhe.de). Structural data for biological macromolecules are collected in the Protein Data Bank (www.rcsb.org/pdb). 

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