Cryptochrome photoreceptor function

Ahmad M, Grancher N, Heil M et al 2002 Action spectrum for cryptochrome-dependent hypocotyl growth inhibition in Arabidopsis. Plant Physiol 129 774-785 Bellingham J, Whitmore D, Philp AR, Wells DJ, Foster RG 2002 Zebrafish melanopsin isolation, tissue localisation and phylogenetic position. Brain Res Mol Brain Res 107 128-136 Crawford BH 1949 The scotopic visibility function. Proc Phys Soc Lond B62 321—334 Miyashita Y, Moriya T, Yamada K et al 2001 The photoreceptor molecules in Xenopus tadpole tail fin, in which melanophores exist. Zool Sci 18 671-674 Wald G 1945 The spectral sensitivity of the human eye a spectral adaptometer. J Opt Soc Am 35 187... 

Sargent ML, Briggs WR, Woodward DO 1966 Circadian nature of a rhythm expressed by an invertaseless strain of Neurospora crassa. Plant Physiol 41 1343—1349 Selby CP, Thompson C, Schmitz TM, Van Gelder RN, Sancar A 2000 Functional redundancy of cryptochromes and classical photoreceptors for nonvisual ocular photoreception in mice. Proc Natl Acad Sci USA 97 14697-14702... 

Helfrich-Forster C, Winter C, Hofbauer A, Hall JC, Stanewsky R 2001 The circadian clock of fruit flies is blind after elimination of all known photoreceptors. Neuron 30 249-261 Lin FJ, Song W, Meyer-Bernstein E, Naidoo N, Sehgal A 2001 Photic signaling by cryptochrome in the Drosophilacitcidiaa system. Mol Cell Biol 21 7287-7294 Mas P, Devlin PF, Panda S, Kay SA 2000 Functional Interaction of phytochrome B and cryptochrome 2. Nature 408 207-211... 

Figure 23.2. Reaction mechanism of PD-DNA photolyase. A photon of blue light is absorbed by the MTHF chromophore that acts as a photoantenna. The excited energy is transferred to the flavin chromophore (FADFF). The excited flavin (FADFI ) acts as a photocatalyst and transfers an electron to a CPD in DNA. The thymines are restored to their native state and the electron is transferred back to the flavin. (Reproduced with permission from Sancar, A. Structure and function of DNA photolyase cryptochrome blue-light photoreceptors. Chem. Rev. 103, 2203-2237, 2003.)...

Sancar, A. Structure and function of DNA photolyase cryptochrome blue-light photoreceptors. Chem Rev. 103, 2203-2237, 2003. 

Structure and function of DNA photolyase and cryptochrome blue-light photoreceptors 03CRV2203. 

Redox reactions have been proposed to play a key role in light-responsive activities of cryptochromes [98, 99], blue-light photoreceptors in plants, animals, and bacteria with widespread functions ranging from the regulation of circadian rhythms of plants and animals [13] to the sensing of magnetic fields in a number of species... 

Cryptochrome/photolyase blue light photoreceptor family. The photoreceptors in this family are flavoproteins. They have a wide range of functions including circadian clock regulation, seed germination, and pigment accumulation. 

Selby, C. P., Thompson, G., Therese, S. M., Van Gelder, R. N., and Sancar, A. (2000). Functional redundancy of cryptochromes and classical photoreceptors for nonvisual ocular photoreception in mice. Proc. Natl. Acad. Sci. USA 97, 14697-14702. 

A. Sancar, Structure and Function of DNA Photolyase and Cryptochrome Blue-Light Photoreceptors, Chem. Rev. 103 (2003) 2203. 

Typical photoreceptor proteins are chlorophyllic protein complexes, and proteins belonging to the carotenoid (rhodopsin), phytochrome, and cryptochrome families [10], These function as light-harvesting antenna pigments and auxiliary cofactors in the photosynthetic process, or they may play a regulatory role in biological processes. The chemical structures of typical chromophoric groups contained in these proteins are presented in Table 3.4. 

While cryptochrome s role in the circadian clock mechanism is clear, its light-dependent function remains to be elucidated. The evidence for cryptochrome as a blue-light circadian photoreceptor is the following ... 

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