Photoreceptors, blue-light photolyase

Figure 23.2. Reaction mechanism of PD-DNA photolyase. A photon of blue light is absorbed by the MTHF chromophore that acts as a photoantenna. The excited energy is transferred to the flavin chromophore (FADFF). The excited flavin (FADFI ) acts as a photocatalyst and transfers an electron to a CPD in DNA. The thymines are restored to their native state and the electron is transferred back to the flavin. (Reproduced with permission from Sancar, A. Structure and function of DNA photolyase cryptochrome blue-light photoreceptors. Chem. Rev. 103, 2203-2237, 2003.)...

Sancar, A. Structure and function of DNA photolyase cryptochrome blue-light photoreceptors. Chem Rev. 103, 2203-2237, 2003. 

Fig. 3. Examples of natural photoantenna chromophores (2) 5,10-methenyltetrahydrofolate (MTHF), a blue light photoreceptor pigment present in photolyase and some cryptochromes (3) Pheophytin a, the primary electron acceptor in cyanobacterial oxygenic photosynthesis. (4) 11-cis-retinal, which is involved as sensory photoreceptor component in the opsin-based visual process of animals and (5) the p-hydroxy-benzylidene-imidazolinone chromophore (HBDI) of the green fluorescent protein from bioluminescent marine species.

Structure and function of DNA photolyase and cryptochrome blue-light photoreceptors 03CRV2203. 

Cryptochrome/photolyase blue light photoreceptor family. The photoreceptors in this family are flavoproteins. They have a wide range of functions including circadian clock regulation, seed germination, and pigment accumulation. 

Miyazawa, Y., H. Nishioka, et al. (2008). Discrimination of class I cyclobutane pyrimidine dimer photolyase from blue light photoreceptors by single methionine residue. Biophysics Journal 94(6) 2194-2203. 

Malhotra, K., Kim, S. T., Batschauer, A., Dawut, L., and Sancar, A. (1995). Putative blue-light photoreceptors from Arabidopsis thaliana and Sinapsis alba with a high degree of sequence homology to DNA photolyase cofactors but lack DNA repair activity. Biochemistry 34, 6892-6899. 

Sancar, A., Thompson, C. L., Thresher, R. J., Araujo, F., Mo, J., Ozgur, S., Vagas, E., Dawut, L., and Selby, C. P. (2000). Photolyase/cryptochrome family blue-light photoreceptors use light energy to repair DNA or set the circadian clock. CM Spring Harbor Symp. Quant. Biol. 65, 157—171. 

Thompson, C. L., and Sancar, A. (2002). Photolyase/cryptochrome blue-light photoreceptors use photon energy to repair DNA and reset the circadian clock. Oncogene 21, 9043-9056. 

Todo, T., Ryo, H., Yamamoto, K., Toh, H., Inui, T., Ayaki, H., Nomura, T., andlkenage, M. (1996). Similarity among the Drosophila (6-4) photolyase, a human photolyase homolog and the DNA photolyase blue light photoreceptor family. Science 272,109-112. 

Worthington, E. N., Kavakli, I. H., Berrocal-Tito, G., Bondo, B. E., and Sancar, A. (2003). Purification and characterization of three members of the photolyase/ cryptochrome family blue-light photoreceptors from Vibrio chokrae. J. Biol. Chem. 278, 3914T-39154. 

Photoantennas in the majority of photolyase/cryptochrome blue-light photoreceptors. 

A. Sancar, Structure and Function of DNA Photolyase and Cryptochrome Blue-Light Photoreceptors, Chem. Rev. 103 (2003) 2203. 

Sancar, A. (2003) Structure and fimction of DNA photolyase and cryptochrome blue-light photoreceptors. Chem. Rev., 103,... 

Hoffman, RD., Batschauer, A., and Hays, J.B., PHHl, a novel gene from Arabidopsis thaliana that encodes a protein similar to plant blue-light photoreceptors and microbial photolyases. Mol. Gen. Genet, 253, 259, 1996. 

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