Crosslinking gelatin with

Zhang, X., Do, M. D., Casey, R, Suiistio, A., Qiao, G. G., Lundin, L., Lillford, R, Kosaraju, S. [2010]. Chemical crosslinking gelatin with natural phenolic compounds as studied by high-resolution NMR spectroscopy, Biomacromoiecuies, 11,1125-1132. 

Gringius, L and Sjo.stcdt, G.. Crosslinking of gelatin with formaldehyde in the presence of some polyhydroxybenzenes, Angew. Mak-romol. Chem., 42, 123, 1975. 

Johnson, R.H. Rowe, E.L. Medicinal Dosage Forms of Superunpolymerized Thiolated Gelatin with a Crosslinking Accelerating Agent Providing Slowly Released Medication from a Swollen Matrix. US Patent 3,574,820, April 13, 1971. 

An example of the first application is shown in Figure 2, which shows release of the highly water-insoluble hydrocortisone acetate from a gelatin matrix crosslinked with formaldehyde (J ). As indicated by the first-order dependence, drug is released by a simple diffusional process and the crosslinked gelatin simply provides cohesiveness for the drug particles. 

A Salmonella typhimurium reverse mutation test for determination of potential mutagenic activity of the crosslinked gelatin microcarrier component was performed with Spheramine. 

Takahashi, T. (1992) Tbc mechanism of the crosslinking reaction of gelatin with hardener./. Phoiogr. Sci., 40, 212. 

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