Quantitative analysis, cross-polarization magic angle spinning

A 13C nuclear magnetic resonance (NMR) study in solution and in the solid state has been reported for three thermochromic spirooxazines, 29-31.32 From a quantitative analysis of I3C cross-polarization/magic-angle-spinning (CP-MAS) NMR spectra shielding anisotropies were estimated and a correlation of these characteristics with thermochromic activity was suggested. 

Quantitative analysis is a very important component of pharmaceutical analysis. In a number of the publications describing the use of solid-state NMR, the majority of the work has dealt with qualitative studies with brief references to the possibility of quantitative analysis. Under proper data acquisition conditions, solid-state NMR is a quantitative technique that typically provides sufficient selectivity and sensitivity. An excellent guide to the utilization of magic angle spinning and cross-polarization techniques for quantitative solid-state NMR data acquisition has been outlined by Harris (34). 

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