Cross-Coupling of Vinyl Halides with Amides or Carbamates

2 Cross-Coupling of Vinyl Halides with Amides or Carbamates 

By using the Liebeskind catalyst copper(I) thiophene-2-carboxylate (copper salt of L8), the coupling reaction of vinyl iodides and amides proceeded smoothly to give the corresponding enamides (Table 9.7, entry 1) [37]. CuI/DMEDA (Lll) was another efficient catalytic system for the coupling of vinyl halides with amides (entry 2) [38]. 

Although the CuI/L-proline (LI) catalytic system showed no obvious acceleration effect for the coupling of aryl halide and amides, the Ma group found that N,N-dimethylglycine (L2) was a suitable promoter for the coupling reaction of vinyl halides with amides, and, in many cases, the reaction worked at room temperature (entry 3) [39], Another combination (Cu(CH3CN)4PF,s/L15/Rb2C03) was recently found effective for this transformation (entry 4) [40], 

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